The Function of FCGR3B
Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
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Top Gene-Substance Interactions
Substances That Increase FCGR3B
| Substances | Interaction | Organism | Category |
Substances That Decrease FCGR3B
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils.
Gene Pathways:
Biological Processes:
- Immune Response
- Mitophagy In Response To Mitochondrial Depolarization
- Positive Regulation Of Defense Response To Virus By Host
- Xenophagy
Drug Bank:
- Abciximab
- Adalimumab
- Alefacept
- Alemtuzumab
- Basiliximab
- Bevacizumab
- Cetuximab
- Daclizumab
- Efalizumab
- Etanercept
- Gemtuzumab Ozogamicin
- Ibritumomab
- Intravenous Immunoglobulin
- Muromonab
- Natalizumab
- Palivizumab
- Tositumomab
- Trastuzumab
- Rituximab