The Function of FBLN5
Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537). Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:10428823). May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108).
- RS7153027 (FBLN5) ??
- RS7154721 (FBLN5) ??
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Top Gene-Substance Interactions
FBLN5 Interacts with These Diseases
| Disease | Score |
Substances That Increase FBLN5
| Substances | Interaction | Organism | Category |
Substances That Decrease FBLN5
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in skin fibroblasts (at protein level)(PubMed:17035250). Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes (PubMed:10428823).
Gene Pathways:
Molecular Function:
Biological Processes:
- Regulation Of Cell Growth
- Cell-Matrix Adhesion
- Extracellular Matrix Organization
- Protein Localization To Cell Surface
- Secretion
- Elastic Fiber Assembly
- Regulation Of Removal Of Superoxide Radicals