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  3. FBLN5

FBLN5 (Fibulin 5)

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The Function of FBLN5

Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537). Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:10428823). May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108).

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FBLN5 SNPs

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  1. RS7153027 (FBLN5) ??
  2. RS7154721 (FBLN5) ??

Top Gene-Substance Interactions

FBLN5 Interacts with These Diseases

Disease Score

Substances That Increase FBLN5

Substances Interaction Organism Category

Substances That Decrease FBLN5

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun

Tissue specificity:

Expressed in skin fibroblasts (at protein level)(PubMed:17035250). Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes (PubMed:10428823).

Gene Pathways:

  • Extracellular matrix organization

Molecular Function:

  • Calcium Ion Binding
  • Integrin Binding
  • Protein C-Terminus Binding
  • Protein Homodimerization Activity

Biological Processes:

  • Cell-Matrix Adhesion
  • Elastic Fiber Assembly
  • Extracellular Matrix Organization
  • Protein Localization To Cell Surface
  • Regulation Of Cell Growth
  • Regulation Of Removal Of Superoxide Radicals
  • Secretion
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_03337| A55| ADCL2| ARCL1A| ARMD3| AS27_04548| AS28_13636| dance| developmental arteries and neural crest EGF-like protein| EH28_23667| embryonic vascular EGF repeat-containing protein| EVEC| FIBL-5| Fibulin-5| H920_20367| HNARMD| M959_10870| MDA_GLEAN10015652| N300_00564| N301_10534| N302_00073| N303_11909| N305_01317| N306_04572| N307_08438| N308_06944| N309_04995| N310_04410| N311_02112| N312_11593| N321_08031| N322_03595| N324_06193| N327_03813| N328_04305| N329_13174| N330_10852| N331_02205| N332_04911| N333_11219| N334_14440| N335_00670| N336_11449| N339_08331| N341_03137| PAL_GLEAN10020769| PANDA_019067| testis tissue sperm-binding protein Li 75n| UP50| urine p50 protein| Y956_05713| Z169_08793| fbln5

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