Summary of FAT1
This gene encodes a protein that plays a role in cell movement and cell-cell contact. It also helps suppress tumors (R).
The Function of FAT1
Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.
Protein names
Recommended name:
Protocadherin Fat 1Alternative name(s):
Cadherin family member 7Cadherin-related tumor suppressor homolog
Protein fat homolog
- RS2637777 (FAT1) ??
- RS925642 (FAT1) ??
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Top Gene-Substance Interactions
FAT1 Interacts with These Diseases
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Substances That Increase FAT1
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Substances That Decrease FAT1
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Advanced Summary
Covered on Genetics Home Reference: head and neck squamous cell carcinoma
From NCBI Gene: This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008] From UniProt: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in many epithelial and some endothelial and smooth muscle cells.
Molecular Function:
Biological Processes:
- Actin Filament Organization
- Anatomical Structure Morphogenesis
- Cell Adhesion
- Cell-Cell Signaling
- Establishment Or Maintenance Of Cell Polarity
- Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
- Single Organismal Cell-Cell Adhesion