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FAT1 (FAT atypical cadherin 1)

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Summary of FAT1

This gene encodes a protein that plays a role in cell movement and cell-cell contact. It also helps suppress tumors (R).

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The Function of FAT1

Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.

Protein names

Recommended name:

Protocadherin Fat 1

Alternative name(s):

Cadherin family member 7
Cadherin-related tumor suppressor homolog
Protein fat homolog

FAT1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2637777 (FAT1) ??
  2. RS925642 (FAT1) ??

Top Gene-Substance Interactions

FAT1 Interacts with These Diseases

Disease Score

Substances That Increase FAT1

Substances Interaction Organism Category

Substances That Decrease FAT1

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: head and neck squamous cell carcinoma

     From NCBI Gene: This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008] From UniProt: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • AP-1
  • c-Jun
  • NF-kappaB1
  • PPAR-alpha
  • c-Fos

Tissue specificity:

Expressed in many epithelial and some endothelial and smooth muscle cells.

Molecular Function:

  • Calcium Ion Binding

Biological Processes:

  • Actin Filament Organization
  • Anatomical Structure Morphogenesis
  • Cell Adhesion
  • Cell-Cell Signaling
  • Establishment Or Maintenance Of Cell Polarity
  • Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
  • Single Organismal Cell-Cell Adhesion
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_11706| Anapl_04567| AS27_13313| AS28_03498| cadherin family member 7| cadherin FAT1 isoform +12| cadherin ME5| cadherin-related family member 8| cadherin-related tumor suppressor homolog| CB1_000362020| CDHF7| CDHR8| D623_10012188| FAT| fat 1 cadherin| Fath| FAT tumor suppressor 1| FAT tumor suppressor homolog 1| FAT tumor suppressor homolog 1 (Drosophila)| GW7_01942| H920_03470| hFat1| M959_12683| MDA_GLEAN10004204| me5| mFat1| N300_04164| N301_12021| N302_04140| N303_02679| N306_04682| N307_06779| N308_01475| N309_15515| N310_13778| N311_12749| N322_11736| N329_12811| N330_11670| N331_12130| N336_12312| N339_00954| N341_02556| PAL_GLEAN10021677| PANDA_009494| protein fat homolog| Protocadherin Fat 1| TREES_T100012408| UY3_09736| Y1Q_030576| Y956_01151| Z169_11223| fat1

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