Summary of FASLG
This gene encodes a protein that is important for immune system regulation and DNA transcription. Mutations can cause lung cancer (R).
The Function of FASLG
The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.
Protein names
Recommended name:
Tumor necrosis factor ligand superfamily member 6Short name:
APLAlternative name(s):
Apoptosis antigen ligandAPTL
CD95 ligand
CD95-L
Fas antigen ligand
Fas ligand
FasL
CD antigen CD178
Receptor-binding FasL ectodomain
Soluble Fas ligand
sFasL
FasL ICD
SPPL2A-processed FasL form
SPA
- RS763110 (FASLG) ??
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Top Gene-Substance Interactions
FASLG Interacts with These Diseases
| Disease | Score |
Substances That Increase FASLG
| Substances | Interaction | Organism | Category |
Substances That Decrease FASLG
| Substances | Interaction | Organism | Category |
Advanced Summary
Covered on Genetics Home Reference: autoimmune lymphoproliferative syndromeFrom NCBI Gene: Lung cancerAutoimmune lymphoproliferative syndromeFrom UniProt: Autoimmune lymphoproliferative syndrome 1B (ALPS1B): A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia. [MIM:601859]
From NCBI Gene: This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014] From UniProt: The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition. Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
- Cytokine-cytokine receptor interaction
- Apoptosis
- Chagas disease (American trypanosomiasis)
- Pathways in cancer
- Allograft rejection
- Neurotrophin signaling pathway
- Type I diabetes mellitus
- Graft-versus-host disease
- Autoimmune thyroid disease
- Measles
- Apoptosis
- MAPK signaling pathway
- Natural killer cell mediated cytotoxicity
- African trypanosomiasis
Molecular Function:
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Transcription, Dna-Templated
- Apoptotic Process
- Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Inflammatory Cell Apoptotic Process
- Immune Response
- Signal Transduction
- Cell-Cell Signaling
- Positive Regulation Of Cell Proliferation
- Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
- Negative Regulation Of Angiogenesis
- Cellular Chloride Ion Homeostasis
- Response To Lipopolysaccharide
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Positive Regulation Of Neuron Apoptotic Process
- Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
- Retinal Cell Programmed Cell Death
- Endosomal Lumen Acidification
- T Cell Apoptotic Process
- Necroptotic Process
- Response To Growth Factor
- Apoptotic Signaling Pathway
- Extrinsic Apoptotic Signaling Pathway
- Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
- Necroptotic Signaling Pathway
- Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
- Positive Regulation Of Endothelial Cell Apoptotic Process