Summary of FAS
This gene encodes a protein that helps with cell signaling. Mutations can cause cancer (R).
The Function of FAS
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Protein names
Recommended name:
Tumor necrosis factor receptor superfamily member 6Alternative name(s):
Apo-1 antigenApoptosis-mediating surface antigen FAS
FASLG receptor
CD antigen CD95
- RS1800682 (FAS) ??
- RS2234978 (FAS) ??
- RS2296603 (FAS) ??
- RS4406737 (FAS) ??
- RS7920888 (FAS) ??
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Top Gene-Substance Interactions
FAS Interacts with These Diseases
Disease | Score |
Substances That Increase FAS
Substances | Interaction | Organism | Category |
Substances That Decrease FAS
Substances | Interaction | Organism | Category |
Advanced Summary
autoimmune lymphoproliferative syndrome More than 100 mutations in the FAS gene have been identified in people with a disorder of the immune system called autoimmune lymphoproliferative syndrome (ALPS). ALPS is characterized by the production of an abnormally large number of immune system cells (lymphocytes), resulting in enlargement of the lymph nodes (lymphadenopathy), the liver (hepatomegaly), and the spleen (splenomegaly). Autoimmune disorders, in which the immune system malfunctions and attacks the body's own tissues and organs, are also common in ALPS. People with ALPS have an increased risk of developing cancer of the immune system cells (lymphoma) and may also be at increased risk of developing other cancers. When the immune system is activated to fight an infection, large numbers of lymphocytes are produced. Normally, these lymphocytes undergo apoptosis when they are no longer required. FAS gene mutations result in an abnormal trimer that interferes with the initiation of apoptosis. Excess lymphocytes accumulate in the body's tissues and organs and often begin attacking them, leading to autoimmune disorders. Interference with apoptosis allows cells to multiply without control, leading to the lymphomas and other cancers that occur in people with this disorder. cancers Studies have associated certain FAS gene variations with increased risk of developing cancer, including cancers of the lung, breast, and esophagus. Researchers believe that these variations may affect the signaling that initiates apoptosis, increasing the risk that cells will multiply out of control and result in cancer.
The FAS gene provides instructions for making a protein that is involved in signaling. Three FAS proteins group together to form a structure called a trimer, which then interacts with other molecules to perform its signaling function. This signaling initiates a process called a caspase cascade. The caspase cascade is a series of steps that results in the self-destruction of cells (apoptosis) when they are not needed.
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
Gene Pathways:
- Cytokine-cytokine receptor interaction
- Apoptosis
- Chagas disease (American trypanosomiasis)
- Pathways in cancer
- Allograft rejection
- Type I diabetes mellitus
- Graft-versus-host disease
- Autoimmune thyroid disease
- Alzheimer's disease
- Measles
- Apoptosis
- p53 signaling pathway
- MAPK signaling pathway
- Natural killer cell mediated cytotoxicity
- African trypanosomiasis
Molecular Function:
- Kinase Binding
- Receptor Activity
- Signal Transducer Activity
- Tumor Necrosis Factor-Activated Receptor Activity
- 3-Hydroxyoctanoyl-
- 3-Oxoacyl-
- 3-Oxoacyl-
- 3-Oxo-Pimeloyl-
- Cadherin Binding Involved In Cell-Cell Adhesion
- Drug Binding
- Enoyl-
- Enoyl-
- Fatty Acid Synthase Activity
- Myristoyl-
- Nadph Binding
- Phosphopantetheine Binding
- Poly(A) Rna Binding
- Identical Protein Binding
Biological Processes:
- Activation-Induced Cell Death Of T Cells
- Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
- Apoptotic Process
- Apoptotic Signaling Pathway
- B Cell Mediated Immunity
- Brain Development
- Cellular Response To Hyperoxia
- Cellular Response To Lithium Ion
- Cellular Response To Mechanical Stimulus
- Circadian Rhythm
- Extrinsic Apoptotic Signaling Pathway
- Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
- Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
- Gene Expression
- Hepatocyte Apoptotic Process
- Immune Response
- Immunoglobulin Production
- Inflammatory Cell Apoptotic Process
- Inflammatory Response
- Motor Neuron Apoptotic Process
- Necroptotic Signaling Pathway
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of B Cell Activation
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
- Negative Thymic T Cell Selection
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
- Positive Regulation Of Lymphocyte Apoptotic Process
- Positive Regulation Of Mapk Cascade
- Positive Regulation Of Protein Homooligomerization
- Protein Complex Assembly
- Protein Homooligomerization
- Regulation Of Apoptotic Process
- Regulation Of Cell Proliferation
- Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
- Regulation Of Lymphocyte Differentiation
- Regulation Of Myeloid Cell Differentiation
- Renal System Process
- Response To Glucocorticoid
- Response To Lipopolysaccharide
- Response To Toxic Substance
- Signal Transduction
- Spleen Development
- Acetyl-Coa Metabolic Process
- Cellular Response To Interleukin-4
- Fatty Acid Biosynthetic Process
- Fatty Acid Metabolic Process
- Long-Chain Fatty-Acyl-Coa Biosynthetic Process
- Mammary Gland Development
- Osteoblast Differentiation
- Pantothenate Metabolic Process
- Positive Regulation Of Cellular Metabolic Process
- Aging
- Cellular Response To Cobalt Ion
- Cellular Response To Estrogen Stimulus
- Cellular Response To Glucose Stimulus
- Cellular Response To Hydrogen Peroxide
- Cellular Response To Hydrostatic Pressure
- Cellular Response To Hypoxia
- Cellular Response To Interleukin-1
- Cellular Response To Phenylalanine
- Chordate Embryonic Development
- Dendrite Regeneration
- Liver Regeneration
- Maternal Process Involved In Female Pregnancy
- Ovarian Follicle Atresia
- Ovulation Cycle
- Regulation Of Gene Expression
- Response To Cycloheximide
- Response To Fluoride
- Response To Growth Factor
- Response To Peptide Hormone
- Spermatogenesis
- Telencephalon Development