Summary of FABP4
This gene encodes a protein that binds to fatty acids in fat cells. It plays a role in fatty acid binding, uptake, transport, and metabolism (R).
Blood levels of FABP4 is linked to severity and treatment of obstructive sleep apnea, as well as the metabolic changes as a result of the apnea (R).
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The Function of FABP4
Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
Protein names
Recommended name:
Fatty acid-binding protein, adipocyteShort name:
ALBPAlternative name(s):
Adipocyte lipid-binding proteinAdipocyte-type fatty acid-binding protein
A-FABP
AFABP
Fatty acid-binding protein 4
- RS1054135 (FABP4) ??
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Top Gene-Substance Interactions
FABP4 Interacts with These Diseases
| Disease | Score |
Substances That Increase FABP4
| Substances | Interaction | Organism | Category |
Substances That Decrease FABP4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Cytokine Production
- Negative Regulation Of Protein Kinase Activity
- Triglyceride Catabolic Process
- Cholesterol Homeostasis
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Inflammatory Response
- White Fat Cell Differentiation
- Brown Fat Cell Differentiation
- Cellular Response To Lithium Ion
- Cellular Response To Tumor Necrosis Factor