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  3. FABP2

FABP2 (Fatty acid binding protein 2)

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The Function of FABP2

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.

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Protein names

Recommended name:

Fatty acid-binding protein, intestinal

Short name:

I-FABP

Alternative name(s):

Fatty acid-binding protein 2
Intestinal-type fatty acid-binding protein

FABP2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10028773 (FABP2) ??

Top Gene-Substance Interactions

FABP2 Interacts with These Diseases

Disease Score

Substances That Increase FABP2

Substances Interaction Organism Category

Substances That Decrease FABP2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-alpha
  • HNF-4alpha1
  • HNF-4alpha2

Tissue specificity:

Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum.

Gene Pathways:

  • PPAR signaling pathway
  • Fat digestion and absorption

Induction:

By EGF.

Molecular Function:

  • Fatty Acid Binding
  • Transporter Activity

Biological Processes:

  • Digestion
  • Triglyceride Catabolic Process

Drug Bank:

  • Sulfinpyrazone
  • Estradiol
  • Ibuprofen
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_08735| AS28_07646| CB1_000816011| EGK_16050| FABP| fabp2-A| fabp2-b| fabpi| fatty acid binding protein 1| fatty acid-binding protein 2| fatty acid binding protein 2, intestinal| fatty acid-binding protein intestinal| Fatty acid-binding protein, intestinal| fatty acid-binding protein, intestinal-like protein| fatty acid-binding protein-like protein| H920_01812| IFABP| I-FABP| I-FABP (FABPI)| intestinal fatty acid binding pr| intestinal fatty acid binding protein| intestinal fatty acid-binding protein| intestinal fatty acid binding protein 2| intestinal-type fatty acid-binding protein| M959_03883| MDA_GLEAN10013416| N301_15497| N302_04855| N303_12223| N305_11094| N306_04431| N307_15127| N308_08429| N309_03204| N311_09427| N312_08929| N320_10409| N321_02488| N322_07744| N324_07890| N325_09202| N326_03316| N327_09333| N328_10899| N329_09965| N330_04901| N331_01877| N332_10071| N333_08608| N335_12507| N336_09379| N339_12948| N340_05926| N341_11561| PAL_GLEAN10013913| PANDA_017867| TREES_T100015054| UY3_04205| Y1Q_014664| Y956_09570| Z169_08392| fabp2

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