The Function of FABP2
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.
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Protein names
Recommended name:
Fatty acid-binding protein, intestinalShort name:
I-FABPAlternative name(s):
Fatty acid-binding protein 2Intestinal-type fatty acid-binding protein
- RS10028773 (FABP2) ??
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Top Gene-Substance Interactions
FABP2 Interacts with These Diseases
| Disease | Score |
Substances That Increase FABP2
| Substances | Interaction | Organism | Category |
Substances That Decrease FABP2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum.
Gene Pathways:
Induction:
By EGF.