• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. F9

F9 (Coagulation factor IX)

Loading...

Summary of F9

This gene encodes a protein called coagulation factor IX, which helps form blood clots. Mutations can cause blood clots to be unable to form and lead to excessive bleeding (hemophilia) or warfarin sensitivity, which can cause severe bleeding problems (R).

0 users want this gene increased, 0 users want it decreased

The Function of F9

Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.

Protein names

Recommended name:

Coagulation factor IX

Short name:

PTC

Alternative name(s):

Christmas factor
Plasma thromboplastin component

F9 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS6048 (F9) ??

Top Gene-Substance Interactions

F9 Interacts with These Diseases

Disease Score

Substances That Increase F9

Substances Interaction Organism Category

Substances That Decrease F9

Substances Interaction Organism Category

Advanced Summary

     hemophilia Mutations in the F9 gene cause a type of hemophilia called hemophilia B. More than 900 alterations in this gene have been identified. The most common mutations change single DNA building blocks (base pairs) in the gene. A small percentage of mutations delete or insert multiple base pairs or rearrange segments of DNA within the gene. Mutations in the F9 gene lead to the production of an abnormal version of coagulation factor IX or reduce the amount of this protein. The altered or missing protein cannot participate effectively in the blood clotting process. As a result, blood clots cannot form properly in response to injury. These problems with blood clotting lead to excessive bleeding that can be difficult to control. Mutations that completely eliminate the activity of coagulation factor IX result in severe hemophilia. Mutations that reduce but do not eliminate the protein's activity usually cause mild or moderate hemophilia. Several mutations near the beginning of the F9 gene sequence cause an unusual form of hemophilia known as hemophilia B Leyden. People with these mutations are born with very low levels of functional coagulation factor IX, but hormonal changes cause the levels of this protein to increase gradually during puberty. As a result, adults with hemophilia B Leyden rarely experience episodes of abnormal bleeding. warfarin sensitivity Genetics Home Reference provides information about warfarin sensitivity. other disorders Several rare mutations in the F9 gene cause an increased sensitivity (hypersensitivity) to a drug called warfarin. This medication is an anticoagulant, which means it is used to prevent the formation or growth of abnormal blood clots. Warfarin works by reducing the amount of active factor IX and three other coagulation proteins. The mutations responsible for warfarin hypersensitivity each change a single base pair in the F9 gene. These mutations do not cause hemophilia B, and people with these genetic changes only have bleeding problems if they are treated with warfarin. Warfarin reduces the amount of coagulation factor IX to very low levels in these individuals, which prevents the blood from clotting normally and can lead to recurrent, severe bleeding problems. To avoid these complications, people with warfarin hypersensitivity can be treated with other anticoagulant medications.

     The F9 gene provides instructions for making a protein called coagulation factor IX. Coagulation factors are a group of related proteins that are essential for the formation of blood clots. After an injury, clots protect the body by sealing off damaged blood vessels and preventing further blood loss. Coagulation factor IX is made in the liver. This protein circulates in the bloodstream in an inactive form until an injury that damages blood vessels occurs. In response to injury, coagulation factor IX is activated by another coagulation factor called factor XIa. The active protein (sometimes written as coagulation factor IXa) interacts with coagulation factor VIII and other molecules. These interactions set off a chain of additional chemical reactions that form a blood clot.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

Tissue specificity:

Detected in blood plasma (at protein level) (PubMed:3857619, PubMed:8295821, PubMed:2592373, PubMed:9169594, PubMed:19846852). Synthesized primarily in the liver and secreted in plasma.

Gene Pathways:

  • Metabolism of proteins
  • Hemostasis
  • Complement and coagulation cascades

Molecular Function:

  • Calcium Ion Binding
  • Endopeptidase Activity
  • Serine-Type Endopeptidase Activity

Biological Processes:

  • Blood Coagulation
  • Blood Coagulation, Extrinsic Pathway
  • Blood Coagulation, Intrinsic Pathway
  • Er To Golgi Vesicle-Mediated Transport
  • Peptidyl-Glutamic Acid Carboxylation
  • Proteolysis
  • Signal Peptide Processing
  • Zymogen Activation

Drug Bank:

  • Antihemophilic Factor (Recombinant)
  • Menadione
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| PTC| P19| vitamin K dependent serine protease| coagulation factor X| A306_13842| AS27_00754| AS28_06900| CB1_012758004| Cf9| Cf-9| christmas factor| coagulation factor 9| coagulation factor 9 (plasma thromboplastic component, Christmas disease, hemophilia B)| coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B)| coagulation factor IX precursor| coagulation factor IX protein| coagulation factor X-like protein| D623_10016643| F9 p22| factor 9| factor IX| factor IX activated protein| factor IX F9| fix| FIXA| gla domain| GW7_05625| H920_12256| hemb| hemophilia B| I79_007664| M959_08088| MDA_GLEAN10002826| N300_04739| N301_11215| N302_05779| N303_10524| N307_05366| N308_01347| N309_00492| N310_10609| N311_03475| N312_05995| N322_00664| N324_00384| N325_01932| N326_01765| N330_04874| N331_06181| N332_07336| N333_07572| N339_04371| PAL_GLEAN10007722| PANDA_009140| plasma thromboplastic component| plasma thromboplastin component| THPH8| TREES_T100012442| UY3_07322| Y1Q_021740| f9

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved