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  3. F3

F3 (Coagulation factor III, tissue factor)

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Summary of F3

This is also known as CNTN1. It encodes a protein that works as a cell adhesion molecule and also helps form axons (R). 

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The Function of F3

Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.

Protein names

Recommended name:

Tissue factor

Short name:

TF

Alternative name(s):

Coagulation factor III
Thromboplastin
CD antigen CD142

F3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1146509 (F3) ??
  2. RS12029080 (F3) ??
  3. RS1361600 (F3) ??
  4. RS2022309 (F3) ??

Top Gene-Substance Interactions

F3 Interacts with These Diseases

Disease Score

Substances That Increase F3

Substances Interaction Organism Category

Substances That Decrease F3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • Egr-1
  • AP-1
  • c-Jun
  • NF-kappaB1
  • AREB6
  • Fra-1

Tissue specificity:

Lung, placenta and pancreas.

Gene Pathways:

  • Hemostasis
  • Complement and coagulation cascades

Induction:

TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF-alpha, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response.

Molecular Function:

  • Cytokine Receptor Activity
  • Phospholipid Binding
  • Protease Binding

Biological Processes:

  • Activation Of Blood Coagulation Via Clotting Cascade
  • Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
  • Activation Of Plasma Proteins Involved In Acute Inflammatory Response
  • Blood Coagulation
  • Blood Coagulation, Extrinsic Pathway
  • Cytokine-Mediated Signaling Pathway
  • Positive Regulation Of Angiogenesis
  • Positive Regulation Of Cell Migration
  • Positive Regulation Of Endothelial Cell Proliferation
  • Positive Regulation Of Platelet-Derived Growth Factor Receptor Signaling Pathway
  • Positive Regulation Of Positive Chemotaxis
  • Positive Regulation Of Protein Kinase B Signaling
  • Protein Processing
  • Aging
  • Cellular Response To Hydrogen Peroxide
  • Positive Regulation Of Smooth Muscle Cell Migration
  • Response To Estradiol
  • Response To Fluid Shear Stress
  • Response To Lipopolysaccharide
  • Response To Low-Density Lipoprotein Particle
  • Response To Mechanical Stimulus
  • Response To Temperature Stimulus

Drug Bank:

  • Coagulation Factor Viia
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Tartrate-resistant acid phosphatase type 5| A306_13386| ACP5| AS27_06092| AS28_00204| brain tissue factor| CB1_001428056| CD142| Cf3| Cf-3| coagulation factor 3| coagulation factor III| coagulation factor III (thromboplastin, tissue factor)| F3_BB| GW7_16746| H920_16671| I79_023933| M959_13067| MDA_GLEAN10020416| N300_00892| N301_03481| N302_00631| N303_13304| N305_09404| N306_07028| N307_05804| N308_07398| N309_10121| N310_10393| N311_06569| N312_10231| N320_04517| N321_03776| N322_10837| N324_01676| N325_09159| N326_09437| N327_06904| N328_01445| N329_03987| N330_11057| N331_02618| N332_09339| N333_12085| N334_03707| N335_13964| N336_01441| N339_01654| N340_09023| N341_10734| PAL_GLEAN10023986| PANDA_006344| silk fibroin 3| TF| TFA| thromboplastin| tissue factor| tissue factor-like protein| TREES_T100021156| UY3_12074| Y1Q_021105| Y956_14041| Z169_02292| f3

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