Summary of F3
This is also known as CNTN1. It encodes a protein that works as a cell adhesion molecule and also helps form axons (R).
The Function of F3
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Protein names
Recommended name:
Tissue factorShort name:
TFAlternative name(s):
Coagulation factor IIIThromboplastin
CD antigen CD142
- RS1146509 (F3) ??
- RS12029080 (F3) ??
- RS1361600 (F3) ??
- RS2022309 (F3) ??
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Top Gene-Substance Interactions
F3 Interacts with These Diseases
| Disease | Score |
Substances That Increase F3
| Substances | Interaction | Organism | Category |
Substances That Decrease F3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Lung, placenta and pancreas.
Gene Pathways:
Induction:
TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF-alpha, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response.
Molecular Function:
Biological Processes:
- Positive Regulation Of Endothelial Cell Proliferation
- Activation Of Plasma Proteins Involved In Acute Inflammatory Response
- Activation Of Blood Coagulation Via Clotting Cascade
- Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Aging
- Blood Coagulation
- Blood Coagulation, Extrinsic Pathway
- Response To Temperature Stimulus
- Response To Mechanical Stimulus
- Positive Regulation Of Platelet-Derived Growth Factor Receptor Signaling Pathway
- Positive Regulation Of Smooth Muscle Cell Migration
- Protein Processing
- Cytokine-Mediated Signaling Pathway
- Positive Regulation Of Cell Migration
- Response To Estradiol
- Response To Lipopolysaccharide
- Response To Fluid Shear Stress
- Positive Regulation Of Angiogenesis
- Positive Regulation Of Positive Chemotaxis
- Positive Regulation Of Protein Kinase B Signaling
- Response To Low-Density Lipoprotein Particle
- Cellular Response To Hydrogen Peroxide
Drug Bank:
- Coagulation Factor Viia