The Function of F2R
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.
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Protein names
Recommended name:
Proteinase-activated receptor 1Short name:
PAR-1Alternative name(s):
Coagulation factor II receptorThrombin receptor
- RS17568628 (F2R) ??
- RS2047076 (F2R) ??
- RS2227831 (F2R) ??
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Top Gene-Substance Interactions
F2R Interacts with These Diseases
| Disease | Score |
Substances That Increase F2R
| Substances | Interaction | Organism | Category |
Substances That Decrease F2R
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Platelets and vascular endothelial cells.
Gene Pathways:
Molecular Function:
- G-Protein Alpha-Subunit Binding
- G-Protein Coupled Receptor Activity
- Receptor Binding
- Thrombin-Activated Receptor Activity
- G-Protein Beta-Subunit Binding
Biological Processes:
- Activation Of Mapkk Activity
- Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
- Negative Regulation Of Glomerular Filtration
- Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Inflammatory Response
- G-Protein Coupled Receptor Signaling Pathway
- Phospholipase C-Activating G-Protein Coupled Receptor Signaling Pathway
- Positive Regulation Of Cytosolic Calcium Ion Concentration
- Protein Kinase C-Activating G-Protein Coupled Receptor Signaling Pathway
- Tyrosine Phosphorylation Of Stat Protein
- Stat Protein Import Into Nucleus
- Establishment Of Synaptic Specificity At Neuromuscular Junction
- Blood Coagulation
- Positive Regulation Of Cell Proliferation
- Negative Regulation Of Cell Proliferation
- Response To Wounding
- Anatomical Structure Morphogenesis
- Positive Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Platelet Activation
- Regulation Of Blood Coagulation
- Positive Regulation Of Blood Coagulation
- Positive Regulation Of Cell Migration
- Response To Lipopolysaccharide
- Regulation Of Interleukin-1 Beta Production
- Positive Regulation Of Collagen Biosynthetic Process
- Positive Regulation Of Rho Protein Signal Transduction
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Positive Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Positive Regulation Of Mapk Cascade
- Negative Regulation Of Neuron Apoptotic Process
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Vasoconstriction
- Positive Regulation Of Smooth Muscle Contraction
- Positive Regulation Of Jak-Stat Cascade
- Homeostasis Of Number Of Cells Within A Tissue
- Release Of Sequestered Calcium Ion Into Cytosol
- Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
- Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-Activating G-Protein Coupled Signaling Pathway
- Positive Regulation Of Calcium Ion Transport
- Regulation Of Sensory Perception Of Pain
- Platelet Dense Granule Organization
- Positive Regulation Of Erk1 And Erk2 Cascade
- Negative Regulation Of Renin Secretion Into Blood Stream
- Positive Regulation Of Interleukin-8 Secretion
- Positive Regulation Of Interleukin-6 Secretion