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  3. F2R

F2R (Coagulation factor II thrombin receptor)

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The Function of F2R

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.

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Protein names

Recommended name:

Proteinase-activated receptor 1

Short name:

PAR-1

Alternative name(s):

Coagulation factor II receptor
Thrombin receptor

F2R SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS17568628 (F2R) ??
  2. RS2047076 (F2R) ??
  3. RS2227831 (F2R) ??

Top Gene-Substance Interactions

F2R Interacts with These Diseases

Disease Score

Substances That Increase F2R

Substances Interaction Organism Category

Substances That Decrease F2R

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • CREB
  • deltaCREB
  • Sp1
  • AP-2gamma

Tissue specificity:

Platelets and vascular endothelial cells.

Gene Pathways:

  • Regulation of actin cytoskeleton
  • Signal Transduction
  • Neuroactive ligand-receptor interaction
  • Calcium signaling pathway
  • Hemostasis
  • Complement and coagulation cascades

Molecular Function:

  • G-Protein Alpha-Subunit Binding
  • G-Protein Beta-Subunit Binding
  • G-Protein Coupled Receptor Activity
  • Receptor Binding
  • Thrombin-Activated Receptor Activity

Biological Processes:

  • Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
  • Activation Of Mapkk Activity
  • Anatomical Structure Morphogenesis
  • Blood Coagulation
  • Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
  • Establishment Of Synaptic Specificity At Neuromuscular Junction
  • G-Protein Coupled Receptor Signaling Pathway
  • Homeostasis Of Number Of Cells Within A Tissue
  • Inflammatory Response
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Glomerular Filtration
  • Negative Regulation Of Neuron Apoptotic Process
  • Negative Regulation Of Renin Secretion Into Blood Stream
  • Phospholipase C-Activating G-Protein Coupled Receptor Signaling Pathway
  • Platelet Activation
  • Platelet Dense Granule Organization
  • Positive Regulation Of Blood Coagulation
  • Positive Regulation Of Calcium Ion Transport
  • Positive Regulation Of Cell Migration
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Collagen Biosynthetic Process
  • Positive Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
  • Positive Regulation Of Cytosolic Calcium Ion Concentration
  • Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-Activating G-Protein Coupled Signaling Pathway
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
  • Positive Regulation Of Interleukin-6 Secretion
  • Positive Regulation Of Interleukin-8 Secretion
  • Positive Regulation Of Jak-Stat Cascade
  • Positive Regulation Of Mapk Cascade
  • Positive Regulation Of Phosphatidylinositol 3-Kinase Signaling
  • Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
  • Positive Regulation Of Rho Protein Signal Transduction
  • Positive Regulation Of Smooth Muscle Contraction
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Vasoconstriction
  • Protein Kinase C-Activating G-Protein Coupled Receptor Signaling Pathway
  • Regulation Of Blood Coagulation
  • Regulation Of Interleukin-1 Beta Production
  • Regulation Of Sensory Perception Of Pain
  • Release Of Sequestered Calcium Ion Into Cytosol
  • Response To Lipopolysaccharide
  • Response To Wounding
  • Stat Protein Import Into Nucleus
  • Tyrosine Phosphorylation Of Stat Protein

Drug Bank:

  • Streptokinase
  • Vorapaxar
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_04936| CF2R| coagulation factor 2 (thrombin) receptor| coagulation factor II receptor| coagulation factor II (thrombin) receptor| D623_10035954| H920_03169| HTR| M91_07734| PANDA_015438| par1| PAR-1| PAR1-5A| Protease-activated receptor| protease-activated receptor 1| protease-activated receptor-1| Proteinase-activated receptor 1| thrombin receptor| ThrR| TR| TRGPC| f2r

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