The Function of EZR
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
Protein names
Recommended name:
EzrinAlternative name(s):
CytovillinVillin-2
p81
Top Gene-Substance Interactions
EZR Interacts with These Diseases
| Disease | Score |
Substances That Increase EZR
| Substances | Interaction | Organism | Category |
Substances That Decrease EZR
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied.
Gene Pathways:
Developmental stage:
Very strong staining is detected in the Purkinje cell layer and in part of the molecular layer of the infant brain compared to adult brain.
Enzyme Regulation:
A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding.
Molecular Function:
- Actin Binding
- Microtubule Binding
- Protein Domain Specific Binding
- Protein Kinase A Catalytic Subunit Binding
- Protein Kinase A Regulatory Subunit Binding
- S100 Protein Binding
- Poly(A) Rna Binding
- Cell Adhesion Molecule Binding
- Actin Filament Binding
- Atpase Binding
- Cadherin Binding Involved In Cell-Cell Adhesion
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Intestinal D-Glucose Absorption
- Sphingosine-1-Phosphate Signaling Pathway
- Cytoskeletal Anchoring At Plasma Membrane
- Leukocyte Cell-Cell Adhesion
- Axon Guidance
- Regulation Of Cell Shape
- Positive Regulation Of Gene Expression
- Protein Kinase A Signaling
- Membrane To Membrane Docking
- Microvillus Assembly
- Astral Microtubule Organization
- Actin Cytoskeleton Reorganization
- Receptor Internalization
- Regulation Of Microvillus Length
- Cellular Protein Complex Localization
- Establishment Or Maintenance Of Apical/Basal Cell Polarity
- Positive Regulation Of Multicellular Organism Growth
- Cortical Microtubule Organization
- Filopodium Assembly
- Phosphatidylinositol-Mediated Signaling
- Positive Regulation Of Protein Secretion
- Negative Regulation Of T Cell Receptor Signaling Pathway
- Actin Filament Bundle Assembly
- Establishment Of Centrosome Localization
- Establishment Of Endothelial Barrier
- Negative Regulation Of Erk1 And Erk2 Cascade
- Cellular Response To Camp
- Protein Localization To Cell Cortex
- Establishment Of Protein Localization To Plasma Membrane
- Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
- Negative Regulation Of Interleukin-2 Secretion
- Regulation Of Organelle Assembly
- Terminal Web Assembly
- Positive Regulation Of Protein Localization To Early Endosome
- Positive Regulation Of Cellular Protein Catabolic Process
- Negative Regulation Of P38mapk Cascade
- Positive Regulation Of Early Endosome To Late Endosome Transport