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  3. ESRRA

ESRRA (Estrogen related receptor alpha)

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The Function of ESRRA

Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.

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Protein names

Recommended name:

Steroid hormone receptor ERR1

Alternative name(s):

Estrogen receptor-like 1
Estrogen-related receptor alpha
ERR-alpha
Nuclear receptor subfamily 3 group B member 1

Top Gene-Substance Interactions

ESRRA Interacts with These Diseases

Disease Score

Substances That Increase ESRRA

Substances Interaction Organism Category

Substances That Decrease ESRRA

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • ER-alpha
  • AhR
  • Sp1
  • STAT1beta
  • STAT1alpha
  • Sox9
  • GCNF

Gene Pathways:

  • Gene Expression
  • Organelle biogenesis and maintenance

Induction:

Induced by PGC1alpha in a number of specific cell types including heart, kidney and muscle.

Molecular Function:

  • Dna Binding
  • Protein Domain Specific Binding
  • Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
  • Rna Polymerase Ii Transcription Factor Activity, Ligand-Activated Sequence-Specific Dna Binding
  • Sequence-Specific Dna Binding
  • Steroid Binding
  • Steroid Hormone Receptor Activity
  • Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Zinc Ion Binding

Biological Processes:

  • Cartilage Development
  • Mitochondrion Organization
  • Positive Regulation Of Cellular Response To Insulin Stimulus
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Cell Proliferation
  • Regulation Of Osteoblast Differentiation
  • Regulation Of Osteoclast Differentiation
  • Regulation Of Transcription, Dna-Templated
  • Response To Estradiol
  • Transcription Initiation From Rna Polymerase Ii Promoter
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| D623_10030665| err1| ERRa| ERRalpha| ERR-alpha| Errra| esrl1| esrral| estrogen receptor-like 1| estrogen receptor related 1| estrogen receptor-related receptor alpha| estrogen-related nuclear receptor alpha| estrogen-related receptor 1| estrogen related receptor, alpha| estrogen-related receptor alpha| ESTRRA| GW7_20671| H920_10308| M91_15983| MDA_GLEAN10017953| Nr3b1| nuclear receptor subfamily 3 group B member 1| orphan nuclear receptor| PAL_GLEAN10011421| PANDA_004846| steroid hormone receptor ERR1| Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR-alpha) (Estrogen receptor-like 1)| esrra

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