The Function of ESRRA
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
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Protein names
Recommended name:
Steroid hormone receptor ERR1Alternative name(s):
Estrogen receptor-like 1Estrogen-related receptor alpha
ERR-alpha
Nuclear receptor subfamily 3 group B member 1
Top Gene-Substance Interactions
ESRRA Interacts with These Diseases
| Disease | Score |
Substances That Increase ESRRA
| Substances | Interaction | Organism | Category |
Substances That Decrease ESRRA
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
Induced by PGC1alpha in a number of specific cell types including heart, kidney and muscle.
Molecular Function:
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Dna Binding
- Steroid Hormone Receptor Activity
- Rna Polymerase Ii Transcription Factor Activity, Ligand-Activated Sequence-Specific Dna Binding
- Steroid Binding
- Zinc Ion Binding
- Protein Domain Specific Binding
- Sequence-Specific Dna Binding
Biological Processes:
- Regulation Of Transcription, Dna-Templated
- Transcription Initiation From Rna Polymerase Ii Promoter
- Mitochondrion Organization
- Response To Estradiol
- Regulation Of Cell Proliferation
- Regulation Of Osteoblast Differentiation
- Regulation Of Osteoclast Differentiation
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Cartilage Development
- Positive Regulation Of Cellular Response To Insulin Stimulus