• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. ERRFI1

ERRFI1 (ERBB receptor feedback inhibitor 1)

Loading...

The Function of ERRFI1

Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

ERBB receptor feedback inhibitor 1

Short name:

MIG-6

Alternative name(s):

Mitogen-inducible gene 6 protein

ERRFI1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS225132 (ERRFI1) ??

Top Gene-Substance Interactions

ERRFI1 Interacts with These Diseases

Disease Score

Substances That Increase ERRFI1

Substances Interaction Organism Category

Substances That Decrease ERRFI1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1

Induction:

Levels are very low in quiescent cells. Up-regulated by mitogens.

Molecular Function:

  • Gtpase Activator Activity
  • Protein Kinase Binding

Biological Processes:

  • Cellular Hyperosmotic Response
  • Cellular Response To Dexamethasone Stimulus
  • Cellular Response To Epidermal Growth Factor Stimulus
  • Cellular Response To Insulin Stimulus
  • Cellular Response To Platelet-Derived Growth Factor Stimulus
  • Lung Alveolus Development
  • Lung Epithelium Development
  • Lung Vasculature Development
  • Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
  • Negative Regulation Of Collagen Biosynthetic Process
  • Negative Regulation Of Epidermal Growth Factor-Activated Receptor Activity
  • Negative Regulation Of Erk1 And Erk2 Cascade
  • Negative Regulation Of Interleukin-1 Beta Production
  • Negative Regulation Of Protein Autophosphorylation
  • Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process
  • Regulation Of Keratinocyte Differentiation
  • Regulation Of Type B Pancreatic Cell Proliferation
  • Response To Stress
  • Skin Morphogenesis
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_09865| AS27_03245| AS28_08901| CB1_029410006| EGK_00185| gene 33| GENE-33| gene 33 polypeptide| GW7_09140| H920_00314| M959_03429| MDA_GLEAN10024420| mig-6| MIG6| mitogen-inducible gene 6 protein| mitogen-inducible gene 6 protein homolog| N300_05958| N301_15299| N302_09980| N303_02558| N305_00778| N306_02662| N307_06589| N308_15278| N309_13756| N310_11383| N311_06394| N312_06169| N320_09834| N321_09477| N322_07276| N325_00317| N326_04873| N327_07840| N329_02747| N330_00516| N331_11077| N332_12122| N333_09501| N334_11200| N335_00493| N339_07357| N340_12205| N341_04818| PAL_GLEAN10013044| Ralt| receptor-associated late transducer| RGD1307599| TREES_T100008897| UY3_07555| xmig6| Xxx| Y1Q_020089| Y956_10607| Z169_09421| errfi1

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved