The Function of ERRFI1
Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development.
Protein names
Recommended name:
ERBB receptor feedback inhibitor 1Short name:
MIG-6Alternative name(s):
Mitogen-inducible gene 6 protein- RS225132 (ERRFI1) ??
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Top Gene-Substance Interactions
ERRFI1 Interacts with These Diseases
| Disease | Score |
Substances That Increase ERRFI1
| Substances | Interaction | Organism | Category |
Substances That Decrease ERRFI1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Induction:
Levels are very low in quiescent cells. Up-regulated by mitogens.
Molecular Function:
Biological Processes:
- Response To Stress
- Negative Regulation Of Epidermal Growth Factor-Activated Receptor Activity
- Negative Regulation Of Protein Autophosphorylation
- Negative Regulation Of Interleukin-1 Beta Production
- Cellular Response To Insulin Stimulus
- Negative Regulation Of Collagen Biosynthetic Process
- Cellular Response To Platelet-Derived Growth Factor Stimulus
- Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process
- Skin Morphogenesis
- Regulation Of Keratinocyte Differentiation
- Lung Alveolus Development
- Lung Vasculature Development
- Lung Epithelium Development
- Regulation Of Type B Pancreatic Cell Proliferation
- Negative Regulation Of Erk1 And Erk2 Cascade
- Cellular Response To Epidermal Growth Factor Stimulus
- Cellular Hyperosmotic Response
- Cellular Response To Dexamethasone Stimulus
- Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress