The Function of ERP44
Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum.
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Protein names
Recommended name:
Endoplasmic reticulum resident protein 44Alternative name(s):
ER protein 44ERp44
Thioredoxin domain-containing protein 4
- RS7028939 (ERP44) ??
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Top Gene-Substance Interactions
ERP44 Interacts with These Diseases
| Disease | Score |
Substances That Increase ERP44
| Substances | Interaction | Organism | Category |
Substances That Decrease ERP44
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Induction:
Up-regulated by inducers of the unfolded protein response (UPR), including tunicamycin and dithiothreitol.
Molecular Function:
Biological Processes:
- Protein Folding
- Response To Unfolded Protein
- Glycoprotein Metabolic Process
- Response To Endoplasmic Reticulum Stress
- Cell Redox Homeostasis