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  3. ERP44

ERP44 (Endoplasmic reticulum protein 44)

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The Function of ERP44

Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum.

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Protein names

Recommended name:

Endoplasmic reticulum resident protein 44

Alternative name(s):

ER protein 44
ERp44
Thioredoxin domain-containing protein 4

ERP44 SNPs

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  1. RS7028939 (ERP44) ??

Top Gene-Substance Interactions

ERP44 Interacts with These Diseases

Disease Score

Substances That Increase ERP44

Substances Interaction Organism Category

Substances That Decrease ERP44

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • AP-1
  • c-Jun
  • C/EBPalpha
  • Sp1
  • c-Fos
  • Sox9

Induction:

Up-regulated by inducers of the unfolded protein response (UPR), including tunicamycin and dithiothreitol.

Molecular Function:

  • Protein Disulfide Isomerase Activity

Biological Processes:

  • Cell Redox Homeostasis
  • Glycoprotein Metabolic Process
  • Protein Folding
  • Response To Endoplasmic Reticulum Stress
  • Response To Unfolded Protein
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AL033348| AS27_15906| AS28_02252| BWK4| Endoplasmic reticulum resident protein 44| endoplasmic reticulum resident protein 44kDa| endoplasmic reticulum resident protein 44 kDa| Endoplasmic reticulum resident protein ERp44| ER protein 44| GW7_05026| H920_19538| I79_013434| M91_20263| M959_13559| MDA_GLEAN10021529| N300_10503| N301_04533| N302_10358| N303_04995| N305_08003| N306_00828| N307_15460| N309_06800| N310_02855| N311_03705| N312_02317| N320_06522| N324_01427| N325_05897| N326_01940| N327_01774| N328_02709| N331_01753| N332_05452| N333_09675| N336_03750| N339_02814| N340_04038| N341_12319| PAL_GLEAN10008001| PANDA_002904| PDIA10| protein disulfide isomerase family A, member 10| thioredoxin domain containing 4 (endoplasmic reticulum)| thioredoxin domain-containing protein 4| thioredoxin domain containing protein 4 precursor-like protein| txndc4| UY3_08938| Y1Q_004495| Y956_00755| Z169_15955| erp44

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