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  3. ERLIN2

ERLIN2 (ER lipid raft associated 2)

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The Function of ERLIN2

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed:24217618).

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Protein names

Recommended name:

Erlin-2

Alternative name(s):

Endoplasmic reticulum lipid raft-associated protein 2
Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2
SPFH domain-containing protein 2

Top Gene-Substance Interactions

Substances That Increase ERLIN2

Substances Interaction Organism Category

Substances That Decrease ERLIN2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • HNF-1A
  • Nkx2-5
  • HNF-1
  • c-Myc
  • TGIF

Tissue specificity:

Ubiquitous.

Molecular Function:

  • Cholesterol Binding
  • Protein Tyrosine Kinase Activity
  • Ubiquitin Protein Ligase Binding

Biological Processes:

  • Cholesterol Metabolic Process
  • Er-Associated Ubiquitin-Dependent Protein Catabolic Process
  • Negative Regulation Of Cholesterol Biosynthetic Process
  • Negative Regulation Of Fatty Acid Biosynthetic Process
  • Srebp Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| SPFH domain family, member 2| A306_10645| Anapl_16834| AS27_08351| AS28_11706| C87251| C8orf2| D623_10030460| EGK_18845| EH28_07082| endoplasmic reticulum lipid raft-associated protein 2| erlin-2| erlin2-a| erlin2-b| erlin-2-like protein| GW7_01210| H920_01538| M959_07309| MDA_GLEAN10024939| N300_11712| N301_00663| N302_03436| N303_05422| N305_14532| N306_12893| N307_07626| N308_06870| N309_12557| N310_09715| N336_02479| N340_11110| N341_01635| NET32| PAL_GLEAN10021582| PANDA_005478| RGD1309010| SPFH2| SPFH domain-containing protein 2| SPG18| stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2| TREES_T100003670| Y1Q_019681| Y956_10065| Z169_06994| erlin2

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