The Function of ERLIN2
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed:24217618).
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Protein names
Recommended name:
Erlin-2Alternative name(s):
Endoplasmic reticulum lipid raft-associated protein 2Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2
SPFH domain-containing protein 2
Top Gene-Substance Interactions
Substances That Increase ERLIN2
| Substances | Interaction | Organism | Category |
Substances That Decrease ERLIN2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitous.
Molecular Function:
Biological Processes:
- Cholesterol Metabolic Process
- Er-Associated Ubiquitin-Dependent Protein Catabolic Process
- Negative Regulation Of Cholesterol Biosynthetic Process
- Negative Regulation Of Fatty Acid Biosynthetic Process
- Srebp Signaling Pathway