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  3. ERLIN1

ERLIN1 (ER lipid raft associated 1)

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The Function of ERLIN1

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618).

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Protein names

Recommended name:

Erlin-1

Alternative name(s):

Endoplasmic reticulum lipid raft-associated protein 1
Protein KE04
Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1
SPFH domain-containing protein 1

ERLIN1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11595238 (ERLIN1) ??
  2. RS975752 (ERLIN1) ??

Top Gene-Substance Interactions

Substances That Increase ERLIN1

Substances Interaction Organism Category

Substances That Decrease ERLIN1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • CUTL1
  • CREB
  • deltaCREB
  • C/EBPalpha
  • HNF-4alpha1
  • IRF-1
  • IRF-2
  • c-Myb

Tissue specificity:

Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine.

Caution:

This sequence contains two in frame methionine codon situated in atypical consensus Kozak sequence in the 5'terminus. By homolog comparison, the second ATG was supposed to be the start codon according to PubMed:11118313.

Molecular Function:

  • Cholesterol Binding

Biological Processes:

  • Cholesterol Metabolic Process
  • Er-Associated Ubiquitin-Dependent Protein Catabolic Process
  • Negative Regulation Of Cholesterol Biosynthetic Process
  • Negative Regulation Of Fatty Acid Biosynthetic Process
  • Srebp Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| SPFH domain-containing protein 1| Band_7 23-211 Keo4 (Interim) similar to C.elegans protein C42C1.9| C10orf69| C80197| EGK_19973| EH28_02413| endoplasmic reticulum lipid raft-associated protein 1| erlin-1| erlin-1-like protein| fa10h05| fb19h05| GW7_03403| H920_11430| KE04| KEO4| N300_07548| PAL_GLEAN10018277| PANDA_013640| protein KE04 homolog| RGD1307058| SPFH1| spfh2| SPFH domain family, member 1| SPFH domain family, member 2| SPG62| stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1| TREES_T100012249| Y1Q_004351| erlin1

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