The Function of ERLIN1
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618).
Protein names
Recommended name:
Erlin-1Alternative name(s):
Endoplasmic reticulum lipid raft-associated protein 1Protein KE04
Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1
SPFH domain-containing protein 1
- RS11595238 (ERLIN1) ??
- RS975752 (ERLIN1) ??
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Top Gene-Substance Interactions
Substances That Increase ERLIN1
| Substances | Interaction | Organism | Category |
Substances That Decrease ERLIN1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine.
Caution:
This sequence contains two in frame methionine codon situated in atypical consensus Kozak sequence in the 5'terminus. By homolog comparison, the second ATG was supposed to be the start codon according to PubMed:11118313.
Molecular Function:
Biological Processes:
- Cholesterol Metabolic Process
- Er-Associated Ubiquitin-Dependent Protein Catabolic Process
- Negative Regulation Of Cholesterol Biosynthetic Process
- Negative Regulation Of Fatty Acid Biosynthetic Process
- Srebp Signaling Pathway