Summary of EPO
This gene encodes a protein that helps with red blood cell development (R).
The Function of EPO
Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.
Protein names
Recommended name:
ErythropoietinAlternative name(s):
Epoetin- RS1617640 (EPO) ??
- RS1734907 (EPO) ??
- RS507392 (EPO) ??
- RS551238 (EPO) ??
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Top Gene-Substance Interactions
EPO Interacts with These Diseases
| Disease | Score |
Substances That Increase EPO
| Substances | Interaction | Organism | Category |
Substances That Decrease EPO
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Microvascular complications of diabetes 2From UniProt: Microvascular complications of diabetes 2 (MVCD2): Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. [MIM:612623]
From NCBI Gene: This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008] From UniProt: Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.
Gene Pathways:
Biological Processes:
- Acute-Phase Response
- Aging
- Apoptotic Process
- Blood Circulation
- Cellular Hyperosmotic Response
- Embryo Implantation
- Erythrocyte Differentiation
- Erythrocyte Maturation
- Hemoglobin Biosynthetic Process
- Negative Regulation Of Calcium Ion Transport Into Cytosol
- Negative Regulation Of Cation Channel Activity
- Negative Regulation Of Erythrocyte Apoptotic Process
- Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
- Negative Regulation Of Neuron Death
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Peptidyl-Serine Phosphorylation
- Positive Regulation Of Activated T Cell Proliferation
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Dna Replication
- Positive Regulation Of Erk1 And Erk2 Cascade
- Positive Regulation Of Neuron Projection Development
- Positive Regulation Of Ras Protein Signal Transduction
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein
- Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Hypoxia
- Response To Axon Injury
- Response To Dexamethasone
- Response To Electrical Stimulus
- Response To Estrogen
- Response To Hyperoxia
- Response To Interleukin-1
- Response To Lipopolysaccharide
- Response To Salt Stress
- Response To Testosterone
- Response To Vitamin A
- Signal Transduction