Summary of EPO
This gene encodes a protein that helps with red blood cell development (R).
The Function of EPO
Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.
Protein names
Recommended name:
ErythropoietinAlternative name(s):
Epoetin- RS1617640 (EPO) ??
- RS1734907 (EPO) ??
- RS507392 (EPO) ??
- RS551238 (EPO) ??
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Top Gene-Substance Interactions
EPO Interacts with These Diseases
| Disease | Score |
Substances That Increase EPO
| Substances | Interaction | Organism | Category |
Substances That Decrease EPO
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Microvascular complications of diabetes 2From UniProt: Microvascular complications of diabetes 2 (MVCD2): Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. [MIM:612623]
From NCBI Gene: This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008] From UniProt: Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.
Gene Pathways:
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Apoptotic Process
- Acute-Phase Response
- Signal Transduction
- Embryo Implantation
- Aging
- Blood Circulation
- Positive Regulation Of Cell Proliferation
- Response To Salt Stress
- Negative Regulation Of Calcium Ion Transport Into Cytosol
- Positive Regulation Of Neuron Projection Development
- Peptidyl-Serine Phosphorylation
- Erythrocyte Differentiation
- Response To Lipopolysaccharide
- Response To Vitamin A
- Response To Testosterone
- Positive Regulation Of Activated T Cell Proliferation
- Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein
- Hemoglobin Biosynthetic Process
- Erythrocyte Maturation
- Response To Estrogen
- Positive Regulation Of Dna Replication
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Ras Protein Signal Transduction
- Response To Axon Injury
- Response To Electrical Stimulus
- Response To Hyperoxia
- Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Hypoxia
- Positive Regulation Of Erk1 And Erk2 Cascade
- Response To Interleukin-1
- Cellular Hyperosmotic Response
- Response To Dexamethasone
- Negative Regulation Of Neuron Death
- Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
- Negative Regulation Of Erythrocyte Apoptotic Process
- Negative Regulation Of Cation Channel Activity