The Function of ELOVL6
Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
- RS10011926 (ELOVL6) ??
- RS10012953 (ELOVL6) ??
- RS13148252 (ELOVL6) ??
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Top Gene-Substance Interactions
ELOVL6 Interacts with These Diseases
| Disease | Score |
Substances That Increase ELOVL6
| Substances | Interaction | Organism | Category |
Substances That Decrease ELOVL6
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitous.
Gene Pathways:
Molecular Function:
- 3-Oxo-Arachidoyl-Coa Synthase Activity
- 3-Oxo-Cerotoyl-Coa Synthase Activity
- 3-Oxo-Lignoceronyl-Coa Synthase Activity
- Fatty Acid Elongase Activity
Biological Processes:
- Fatty Acid Elongation, Monounsaturated Fatty Acid
- Fatty Acid Elongation, Polyunsaturated Fatty Acid
- Fatty Acid Elongation, Saturated Fatty Acid
- Long-Chain Fatty Acid Biosynthetic Process
- Long-Chain Fatty-Acyl-Coa Biosynthetic Process
- Sphingolipid Biosynthetic Process
- Unsaturated Fatty Acid Biosynthetic Process
- Very Long-Chain Fatty Acid Biosynthetic Process