The Function of ELK3
May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.
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Protein names
Recommended name:
ETS domain-containing protein Elk-3Short name:
SAP-2Alternative name(s):
ETS-related protein ERPETS-related protein NET
Serum response factor accessory protein 2
SRF accessory protein 2
- RS11835157 (ELK3) ??
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Top Gene-Substance Interactions
Substances That Increase ELK3
| Substances | Interaction | Organism | Category |
Substances That Decrease ELK3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
- Purine-Rich Negative Regulatory Element Binding
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcription Corepressor Activity
- Transcription Factor Activity, Sequence-Specific Dna Binding
Biological Processes:
- Angiogenesis
- Cell Differentiation
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Signal Transduction
- Wound Healing