• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. EIF6

EIF6 (Eukaryotic translation initiation factor 6)

Loading...

The Function of EIF6

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (PubMed:10085284, PubMed:14654845, PubMed:21536732). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:17507929). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.

0 users want this gene increased, 0 users want it decreased

EIF6 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS619865 (EIF6) ??

Top Gene-Substance Interactions

EIF6 Interacts with These Diseases

Disease Score

Substances That Increase EIF6

Substances Interaction Organism Category

Substances That Decrease EIF6

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CREB
  • deltaCREB
  • STAT3
  • C/EBPbeta
  • C/EBPalpha
  • c-Myc
  • STAT1
  • STAT1alpha

Tissue specificity:

Expressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle (at protein level).

Gene Pathways:

  • Ribosome biogenesis in eukaryotes

Molecular Function:

  • Ribosomal Large Subunit Binding
  • Ribosome Binding
  • Translation Initiation Factor Activity

Biological Processes:

  • Assembly Of Large Subunit Precursor Of Preribosome
  • Gene Silencing By Mirna
  • Maturation Of 5.8s Rrna
  • Maturation Of Lsu-Rrna
  • Mature Ribosome Assembly
  • Mirna Mediated Inhibition Of Translation
  • Positive Regulation Of Translation
  • Regulation Of Fatty Acid Biosynthetic Process
  • Regulation Of Glycolytic Process
  • Regulation Of Megakaryocyte Differentiation
  • Regulation Of Reactive Oxygen Species Metabolic Process
  • Response To Insulin
  • Ribosomal Subunit Export From Nucleus
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| CAB| 1110004P11| A306_01918| anon-WO0172774.153| anon-WO0172774.155| AS28_13656| b(2)gcn| B4 integrin interactor| CB1_001108023| CG17611 gene product from transcript CG17611-RA| CG17611-PA| DeIF6| Dmel_CG17611| EGK_02469| eif3a| eIF-6| eIF6-PA| elF6| eukaryotic translation initiation factor 3A| Eukaryotic translation initiation factor 6 isoform 3-like protein| eukaryotic translation initiation factor-like protein| FAM83C| family with sequence similarity 83, member C| if6| imc-415| imc-415 homolog| integrin beta 4 binding protein| Itgb4bp| itgb4bp4| M91_20154| M959_08840| MDA_GLEAN10022752| N300_03311| N301_10052| N302_10601| N303_01435| N305_09152| N306_08154| N307_03476| N308_06403| N309_08434| N310_01860| N311_11473| N320_06459| N321_12404| N322_04241| N324_02923| N328_01771| N329_06815| N330_03360| N331_02414| N333_03377| N334_05018| N340_14877| N341_09975| p27BBP| p27(BBP)| p27 beta-4 integrin-binding protein| PAL_GLEAN10024268| PANDA_004528| Tenascin-R| TNR_0| TREES_T100008599| Y1Q_017650| Z169_04404| eif6

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved