The Function of EIF3H
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Protein names
Recommended name:
Eukaryotic translation initiation factor 3 subunit HAlternative name(s):
eIF3hEukaryotic translation initiation factor 3 subunit 3
eIF-3-gamma
eIF3 p40 subunit
- RS11987235 (EIF3H) ??
- RS16892766 (EIF3H) ??
- RS2278491 (EIF3H) ??
- RS6469656 (EIF3H) ??
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Top Gene-Substance Interactions
EIF3H Interacts with These Diseases
| Disease | Score |
Substances That Increase EIF3H
| Substances | Interaction | Organism | Category |
Substances That Decrease EIF3H
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Formation Of Translation Preinitiation Complex
- Translational Initiation
- Regulation Of Translational Initiation