Summary of EHMT2
This gene encodes a protein that methylates lysine residues of histone H3. This methylation results repression of transcription (R).
The Function of EHMT2
Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.
Protein names
Recommended name:
Histone-lysine N-methyltransferase EHMT2Alternative name(s):
Euchromatic histone-lysine N-methyltransferase 2HLA-B-associated transcript 8
Histone H3-K9 methyltransferase 3
H3-K9-HMTase 3
Lysine N-methyltransferase 1C
Protein G9a
- RS535586 (EHMT2) ??
- RS652888 (EHMT2) ??
- RS9267663 (EHMT2) ??
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Top Gene-Substance Interactions
EHMT2 Interacts with These Diseases
| Disease | Score |
Substances That Increase EHMT2
| Substances | Interaction | Organism | Category |
Substances That Decrease EHMT2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in all tissues examined, with high levels in fetal liver, thymus, lymph node, spleen and peripheral blood leukocytes and lower level in bone marrow.
Gene Pathways:
Caution:
It is uncertain whether Met-1 or Met-21 is the initiator methionine.
Molecular Function:
- P53 Binding
- Zinc Ion Binding
- Protein-Lysine N-Methyltransferase Activity
- Histone-Lysine N-Methyltransferase Activity
- Histone Methyltransferase Activity (H3-K9 Specific)
- Histone Methyltransferase Activity (H3-K27 Specific)
- C2h2 Zinc Finger Domain Binding
- Promoter-Specific Chromatin Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Dna Replication
- Dna Methylation
- Cellular Response To Starvation
- Histone Methylation
- Peptidyl-Lysine Dimethylation
- Histone Lysine Methylation
- Regulation Of Signal Transduction By P53 Class Mediator