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  3. EHMT2

EHMT2 (Euchromatic histone lysine methyltransferase 2)

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Summary of EHMT2

This gene encodes a protein that methylates lysine residues of histone H3. This methylation results repression of transcription (R).

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The Function of EHMT2

Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.

Protein names

Recommended name:

Histone-lysine N-methyltransferase EHMT2

Alternative name(s):

Euchromatic histone-lysine N-methyltransferase 2
HLA-B-associated transcript 8
Histone H3-K9 methyltransferase 3
H3-K9-HMTase 3
Lysine N-methyltransferase 1C
Protein G9a

EHMT2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS535586 (EHMT2) ??
  2. RS652888 (EHMT2) ??
  3. RS9267663 (EHMT2) ??

Top Gene-Substance Interactions

EHMT2 Interacts with These Diseases

Disease Score

Substances That Increase EHMT2

Substances Interaction Organism Category

Substances That Decrease EHMT2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AREB6
  • p300

Tissue specificity:

Expressed in all tissues examined, with high levels in fetal liver, thymus, lymph node, spleen and peripheral blood leukocytes and lower level in bone marrow.

Gene Pathways:

  • Lysine degradation
  • Cellular responses to stress

Caution:

It is uncertain whether Met-1 or Met-21 is the initiator methionine.

Molecular Function:

  • C2h2 Zinc Finger Domain Binding
  • Histone-Lysine N-Methyltransferase Activity
  • Histone Methyltransferase Activity (H3-K27 Specific)
  • Histone Methyltransferase Activity (H3-K9 Specific)
  • P53 Binding
  • Promoter-Specific Chromatin Binding
  • Protein-Lysine N-Methyltransferase Activity
  • Zinc Ion Binding

Biological Processes:

  • Cellular Response To Starvation
  • Dna Methylation
  • Histone Lysine Methylation
  • Histone Methylation
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Peptidyl-Lysine Dimethylation
  • Regulation Of Dna Replication
  • Regulation Of Signal Transduction By P53 Class Mediator
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ankyrin repeat-containing protein| bat8| C6orf30| CB1_000383044| D17Ertd710e| ehmt2a| euchromatic histone lysine N-methyltransferase 2| euchromatic histone-lysine N-methyltransferase 2| euchromatic histone lysine N-methyltransferase 2a| euchromatic histone-lysine N-methyltransferase 2 pseudogene| euchromatic histone lysine N-mthyltransferase EHMT2/G9a| G9a| G9A histone methyltransferase| GAT8| H3-K9-HMTase 3| H920_17562| histone H3-K9 methyltransferase 3| Histone-lysine N-methyltransferase EHMT1| histone-lysine N-methyltransferase EHMT2| Histone-lysine N-methyltransferase, H3 lysine-9 specific 3| HLA-B associated transcript 8| HLA-B-associated transcript 8| HLA-B associated transcript 8, rat orthologue| I79_016441| KMT1C| lysine N-methyltransferase 1C| M91_14114| Ng36| PAL_GLEAN10001068| PANDA_021713| protein G9a| TREES_T100017787| ehmt2

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