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  3. EHBP1

EHBP1 (EH domain binding protein 1)

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Summary of EHBP1

This gene encodes a protein that plays a role in endocytic trafficking and actin reorganization. It is associated with prostate cancer (R).

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The Function of EHBP1

May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton.

Protein names

Recommended name:

EH domain-binding protein 1

EHBP1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11688816 (EHBP1) ??
  2. RS2430386 (EHBP1) ??
  3. RS2710642 (EHBP1) ??
  4. RS2710646 (EHBP1) ??
  5. RS721048 (EHBP1) ??

Top Gene-Substance Interactions

EHBP1 Interacts with These Diseases

Disease Score

Substances That Increase EHBP1

Substances Interaction Organism Category

Substances That Decrease EHBP1

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: prostate cancerFrom NCBI Gene: Prostate cancer, hereditary, 12From UniProt: Prostate cancer, hereditary, 12 (HPC12): A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. [MIM:611868]

     From NCBI Gene: This gene encodes an Eps15 homology domain binding protein. The encoded protein may play a role in endocytic trafficking. A single nucleotide polymorphism in this gene is associated with an aggressive form of prostate cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] From UniProt: May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • HNF-1A
  • HNF-1
  • MEF-2A
  • GATA-1
  • Cdc5
  • GATA-2
  • GATA-3
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| testis tissue sperm-binding protein Li 50e| 2R11| A306_02268| AF424697| AS28_02290| CB1_001609006| CG15609 gene product from transcript CG15609-RI| CG15609-PB| CG15609-PF| CG15609-PG| CG15609-PI| D623_10034291| dEHBP1| dEHBP-1| Dmel_CG15609| DNA sequence AF424697| EGK_05372| Ehbp1-PB| Ehbp1-PF| Ehbp1-PG| Ehbp1-PI| EH domain-binding protein 1| EH domain-binding protein 1-like protein| Eps15 homology domain containing protein-binding protein 1| fc92e03| H920_17521| HPC12| M959_10771| N301_02029| N302_08613| N303_01264| N305_03636| N306_03268| N308_08523| N310_09221| N325_04961| N326_04862| N328_04382| N330_07088| N331_08954| N333_02043| N336_02936| N340_03581| NACSIN| NPF calponin-like protein| PAL_GLEAN10021212| PANDA_010782| RGD1310604| TREES_T100000697| UY3_09945| Y1Q_004670| Y956_07299| Z169_08739| ehbp1

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