Summary of EGF
This gene encodes a protein that plays an important role in the growth and differentiation of numerous cell types. It is associated with higher risk for cancer (R).
The Function of EGF
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941).
Protein names
Recommended name:
Pro-epidermal growth factorShort name:
EGFAlternative name(s):
Urogastrone- RS10012953 (EGF) ??
- RS11568995 (EGF) ??
- RS11569017 (EGF) ??
- RS17316633 (EGF) ??
- RS4444903 (EGF) ??
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Top Gene-Substance Interactions
EGF Interacts with These Diseases
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Substances That Increase EGF
| Substances | Interaction | Organism | Category |
Substances That Decrease EGF
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Advanced Summary
From NCBI Gene: Hypomagnesemia 4, renalFrom UniProt: Hypomagnesemia 4 (HOMG4): A disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to moderate psychomotor retardation, and brisk tendon reflexes. [MIM:611718]
From NCBI Gene: This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016] From UniProt: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941).
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in kidney, salivary gland, cerebrum and prostate.
Gene Pathways:
Molecular Function:
- Calcium Ion Binding
- Epidermal Growth Factor Receptor Binding
- Growth Factor Activity
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
- Protein Tyrosine Kinase Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Transmembrane Receptor Protein Tyrosine Kinase Activator Activity
- Wnt-Activated Receptor Activity
- Wnt-Protein Binding
Biological Processes:
- Activation Of Mapk Activity
- Activation Of Mapkk Activity
- Angiogenesis
- Branching Morphogenesis Of An Epithelial Tube
- Canonical Wnt Signaling Pathway
- Dna Replication
- Epidermal Growth Factor Receptor Signaling Pathway
- Erbb2 Signaling Pathway
- Erk1 And Erk2 Cascade
- Mammary Gland Alveolus Development
- Mapk Cascade
- Negative Regulation Of Cholesterol Efflux
- Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
- Negative Regulation Of Secretion
- Phosphatidylinositol-Mediated Signaling
- Platelet Degranulation
- Positive Regulation Of Catenin Import Into Nucleus
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation
- Positive Regulation Of Dna Binding
- Positive Regulation Of Epidermal Growth Factor-Activated Receptor Activity
- Positive Regulation Of Hyaluronan Biosynthetic Process
- Positive Regulation Of Map Kinase Activity
- Positive Regulation Of Mitotic Nuclear Division
- Positive Regulation Of Peptidyl-Threonine Phosphorylation
- Positive Regulation Of Phosphorylation
- Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-Dependent Protein Catabolic Process
- Positive Regulation Of Transcription, Dna-Templated
- Regulation Of Calcium Ion Import
- Regulation Of Cell Motility
- Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Regulation Of Protein Localization To Cell Surface
- Signal Transduction
- Stat Protein Import Into Nucleus
- Wnt Signaling Pathway Involved In Dorsal/Ventral Axis Specification