The Function of EFNA1
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Protein names
Recommended name:
Ephrin-A1Short name:
LERK-1Alternative name(s):
EPH-related receptor tyrosine kinase ligand 1Immediate early response protein B61
Tumor necrosis factor alpha-induced protein 4
TNF alpha-induced protein 4
- RS11264330 (EFNA1) ??
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Top Gene-Substance Interactions
Substances That Increase EFNA1
| Substances | Interaction | Organism | Category |
Substances That Decrease EFNA1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level).
Gene Pathways:
Induction:
By TNF and IL1B/interleukin-1 beta.
Molecular Function:
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Mapk Cascade
- Activation Of Mapk Activity
- Angiogenesis
- Aortic Valve Morphogenesis
- Mitral Valve Morphogenesis
- Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation
- Cell-Cell Signaling
- Axon Guidance
- Negative Regulation Of Epithelial To Mesenchymal Transition
- Notochord Formation
- Regulation Of Cell Adhesion Mediated By Integrin
- Substrate Adhesion-Dependent Cell Spreading
- Regulation Of Blood Vessel Endothelial Cell Migration
- Regulation Of Angiogenesis
- Ephrin Receptor Signaling Pathway
- Regulation Of Peptidyl-Tyrosine Phosphorylation
- Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
- Regulation Of Axonogenesis
- Negative Regulation Of Dendritic Spine Morphogenesis
- Negative Regulation Of Thymocyte Apoptotic Process