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  3. EFNA1

EFNA1 (Ephrin A1)

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The Function of EFNA1

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.

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Protein names

Recommended name:

Ephrin-A1

Short name:

LERK-1

Alternative name(s):

EPH-related receptor tyrosine kinase ligand 1
Immediate early response protein B61
Tumor necrosis factor alpha-induced protein 4
TNF alpha-induced protein 4

EFNA1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11264330 (EFNA1) ??

Top Gene-Substance Interactions

Substances That Increase EFNA1

Substances Interaction Organism Category

Substances That Decrease EFNA1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • STAT3
  • NF-kappaB1
  • FOXL1

Tissue specificity:

Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level).

Gene Pathways:

  • Axon guidance

Induction:

By TNF and IL1B/interleukin-1 beta.

Molecular Function:

  • Ephrin Receptor Binding
  • Receptor Binding

Biological Processes:

  • Activation Of Mapk Activity
  • Angiogenesis
  • Aortic Valve Morphogenesis
  • Axon Guidance
  • Cell-Cell Signaling
  • Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation
  • Ephrin Receptor Signaling Pathway
  • Mapk Cascade
  • Mitral Valve Morphogenesis
  • Negative Regulation Of Dendritic Spine Morphogenesis
  • Negative Regulation Of Epithelial To Mesenchymal Transition
  • Negative Regulation Of Thymocyte Apoptotic Process
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Notochord Formation
  • Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
  • Regulation Of Angiogenesis
  • Regulation Of Axonogenesis
  • Regulation Of Blood Vessel Endothelial Cell Migration
  • Regulation Of Cell Adhesion Mediated By Integrin
  • Regulation Of Peptidyl-Tyrosine Phosphorylation
  • Substrate Adhesion-Dependent Cell Spreading
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_00536| b61| ECKLG| efl1| efna1-a| efna1-b| epha1| eph-related receptor tyrosine kinase ligand 1| ephrin-A1| Epl1| eplg1| GW7_05196| immediate early response protein B61| Lerk1| LERK-1| ligand of eph-related kinase 1| M91_20862| N341_10036| PANDA_011514| TNFAIP4| TNF alpha-induced protein 4| TREES_T100014138| tumor necrosis factor, alpha-induced protein 4| Xefrin-A1| xelfa| xelf-a| Y1Q_000236| efna1

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