The Function of EDEM2
Initiates the endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. Catalyzes the first mannose trimming step, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle.
Protein names
Recommended name:
ER degradation-enhancing alpha-mannosidase-like protein 2- RS17310467 (EDEM2) ??
- RS2295888 (EDEM2) ??
- RS6060278 (EDEM2) ??
- RS6088735 (EDEM2) ??
- RS6120849 (EDEM2) ??
- RS867186 (EDEM2) ??
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Top Gene-Substance Interactions
Substances That Increase EDEM2
| Substances | Interaction | Organism | Category |
Substances That Decrease EDEM2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle.
Induction:
Up-regulated by the unfolded protein response (UPR) via the XBP1 transcription factor.
Molecular Function:
- Alpha-Mannosidase Activity
- Calcium Ion Binding
- Glycoprotein Binding
- Mannosyl-Oligosaccharide 1,2-Alpha-Mannosidase Activity
Biological Processes:
- Endoplasmic Reticulum Mannose Trimming
- Endoplasmic Reticulum Unfolded Protein Response
- Er-Associated Ubiquitin-Dependent Protein Catabolic Process
- Glycoprotein Erad Pathway
- Mannose Trimming Involved In Glycoprotein Erad Pathway
- N-Glycan Processing
- Positive Regulation Of Retrograde Protein Transport, Er To Cytosol
- Trimming Of Terminal Mannose On B Branch