The Function of ECT2
Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
Protein names
Recommended name:
Protein ECT2Alternative name(s):
Epithelial cell-transforming sequence 2 oncogene- RS7646507 (ECT2) ??
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Top Gene-Substance Interactions
Substances That Increase ECT2
| Substances | Interaction | Organism | Category |
Substances That Decrease ECT2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in lung epithelial cells (at protein level). Expressed in squamous cell carcinoma, primary non-small cell lung cancer tumors and lung adenocarcinoma.
Gene Pathways:
Induction:
Up-regulated by calcium in cells forming cell-cell contact sites. Up-regulated by DNA damaging agents like H(2)O(2) or ionizing radiation (IR).
Molecular Function:
- Gtpase Activator Activity
- Guanyl-Nucleotide Exchange Factor Activity
- Protein Homodimerization Activity
- Rho Guanyl-Nucleotide Exchange Factor Activity
- Signal Transducer Activity
Biological Processes:
- Activation Of Gtpase Activity
- Activation Of Protein Kinase Activity
- Bicellular Tight Junction Assembly
- Cell Morphogenesis
- Cellular Response To Calcium Ion
- Cellular Response To Hydrogen Peroxide
- Cellular Response To Ionizing Radiation
- Cytokinesis
- Intracellular Signal Transduction
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of Cytokinesis
- Positive Regulation Of Gtpase Activity
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Positive Regulation Of Neuron Differentiation
- Positive Regulation Of Protein Import Into Nucleus
- Protein Homooligomerization
- Protein Transport
- Regulation Of Attachment Of Spindle Microtubules To Kinetochore
- Regulation Of Protein Kinase Activity
- Regulation Of Rho Protein Signal Transduction
- Regulation Of Small Gtpase Mediated Signal Transduction