The Function of ECHS1
Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate.
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Protein names
Recommended name:
Enoyl-CoA hydratase, mitochondrialShort name:
SCEHAlternative name(s):
Enoyl-CoA hydratase 1Short-chain enoyl-CoA hydratase
- RS7894051 (ECHS1) ??
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Top Gene-Substance Interactions
ECHS1 Interacts with These Diseases
| Disease | Score |
Substances That Increase ECHS1
| Substances | Interaction | Organism | Category |
Substances That Decrease ECHS1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Liver, fibroblast, muscle. Barely detectable in spleen and kidney.