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  3. ECHS1

ECHS1 (Enoyl-CoA hydratase, short chain 1)

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The Function of ECHS1

Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate.

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Protein names

Recommended name:

Enoyl-CoA hydratase, mitochondrial

Short name:

SCEH

Alternative name(s):

Enoyl-CoA hydratase 1
Short-chain enoyl-CoA hydratase

ECHS1 SNPs

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  1. RS7894051 (ECHS1) ??

Top Gene-Substance Interactions

ECHS1 Interacts with These Diseases

Disease Score

Substances That Increase ECHS1

Substances Interaction Organism Category

Substances That Decrease ECHS1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AP-1
  • Max
  • Arnt
  • c-Jun
  • NF-kappaB1
  • STAT5A
  • c-Myc
  • c-Fos

Tissue specificity:

Liver, fibroblast, muscle. Barely detectable in spleen and kidney.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Butanoate metabolism
  • Fatty acid metabolism
  • Valine, leucine and isoleucine degradation
  • Fatty acid elongation in mitochondria
  • Lysine degradation
  • Tryptophan metabolism
  • Propanoate metabolism
  • beta-Alanine metabolism

Molecular Function:

  • Enoyl-Coa Hydratase Activity

Biological Processes:

  • Fatty Acid Beta-Oxidation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_08807| C80529| cOR6not| D623_10024885| ECHM| ECHS1D| enoyl-CoA hydratase 1| enoyl-CoA hydratase, mitochondrial| enoyl-CoA hydratase, mitochondrial-like protein| enoyl CoA hydratase, short chain, 1, mitochondrial| enoyl-CoA hydratase, short chain, 1, mitochondrial| Enoyl-CoA hydratase, short chain 1, mitochondrial| enoyl Coenzyme A hydratase, short chain 1| enoyl Coenzyme A hydratase, short chain, 1, mitochondrial| fj55e05| I79_024352| M91_14996| MDA_GLEAN10021247| mitochondrial enoyl-CoA hydratase| mitochondrial short-chain enoyl-coenzyme A hydratase 1| N300_07552| N302_09067| N303_09614| N305_10345| N309_14972| N310_01039| N320_08517| N331_00201| PAL_GLEAN10008887| PANDA_018784| SCEH| short chain enoyl-CoA hydratase| short-chain enoyl-CoA hydratase| TREES_T100016869| vertebrate mitochondrial enoyl Coenzyme A hydratase 1-like| Y1Q_016861| Y956_12838| echs1

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