The Function of ECE2
Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide accumulation in brain. May also have methyltransferase activity.
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Protein names
Recommended name:
Endothelin-converting enzyme 2Short name:
ECE-2- RS3914188 (ECE2) ??
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Top Gene-Substance Interactions
Substances That Increase ECE2
| Substances | Interaction | Organism | Category |
Substances That Decrease ECE2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in brain. Strongly down-regulated in inferior parietal lobe from Alzheimer disease patients (at protein level).
Cofactor:
Binds 1 zinc ion per subunit.
Molecular Function:
Biological Processes:
- Brain Development
- Cardioblast Differentiation
- Cell-Cell Signaling
- Heart Development
- Peptide Hormone Processing