The Function of E2F5
Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.
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Protein names
Recommended name:
Transcription factor E2F5Short name:
E2F-5- RS2403083 (E2F5) ??
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Top Gene-Substance Interactions
Substances That Increase E2F5
| Substances | Interaction | Organism | Category |
Substances That Decrease E2F5
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
- Dna Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Binding
Biological Processes:
- Animal Organ Morphogenesis
- Cell Projection Organization
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Cell Cycle
- Transcription, Dna-Templated