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  3. E2F1

E2F1 (E2F transcription factor 1)

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Summary of E2F1

This gene encodes a protein that plays a role in the control of cell cycle. It also affects the action of tumor suppressor proteins (R).

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The Function of E2F1

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812).

Protein names

Recommended name:

Transcription factor E2F1

Short name:

PBR3

Alternative name(s):

E2F-1
Retinoblastoma-associated protein 1
RBAP-1
Retinoblastoma-binding protein 3
RBBP-3
pRB-binding protein E2F-1

E2F1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS3213182 (E2F1) ??

Top Gene-Substance Interactions

E2F1 Interacts with These Diseases

Disease Score

Substances That Increase E2F1

Substances Interaction Organism Category

Substances That Decrease E2F1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • C/EBPalpha
  • E2F-1
  • E2F-4
  • E2F-5
  • c-Myb
  • p300

Gene Pathways:

  • Melanoma
  • Pathways in cancer
  • Signal Transduction
  • Cellular responses to stress
  • Apoptosis
  • Prostate cancer
  • Chronic myeloid leukemia
  • Glioma
  • Pancreatic cancer
  • Small cell lung cancer
  • Bladder cancer
  • Non-small cell lung cancer

Enzyme Regulation:

BIRC2/c-IAP1 stimulates its transcriptional activity.

Molecular Function:

  • Core Promoter Binding
  • Dna Binding
  • Sequence-Specific Dna Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transcription Factor Binding

Biological Processes:

  • Anoikis
  • Cellular Response To Fatty Acid
  • Cellular Response To Hypoxia
  • Cellular Response To Nerve Growth Factor Stimulus
  • Cellular Response To Xenobiotic Stimulus
  • Dna Damage Checkpoint
  • Dna Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
  • Forebrain Development
  • Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
  • Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage
  • Lens Fiber Cell Apoptotic Process
  • Mrna Stabilization
  • Negative Regulation Of Dna Binding
  • Negative Regulation Of Fat Cell Differentiation
  • Negative Regulation Of Fat Cell Proliferation
  • Negative Regulation Of Transcription, Dna-Templated
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
  • Positive Regulation Of Fibroblast Proliferation
  • Positive Regulation Of Gene Expression
  • Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of G1/S Transition Of Mitotic Cell Cycle
  • Regulation Of Transcription, Dna-Templated
  • Spermatogenesis
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_00264| Anapl_11556| AS27_08275| AS28_13670| CB1_000408038| CG6376 gene product from transcript CG6376-RF| CG6376-PA| CG6376-PB| CG6376-PC| CG6376-PD| CG6376-PE| CG6376-PF| D623_10023721| dE2f| dE2f1| def21| DmE2F-1| Dmel_CG6376| Dp| drosE2F1| DRTF1/E2F| e2f| E2F-1| E2f1-PA| E2f1-PB| E2f1-PC| E2f1-PD| E2f1-PE| E2f1-PF| E2F-1 transcription factor| E2F transcription factor| E2-promoter binding factor| E(Sev-CycE)3A| Evar(3)164| E(var)3-93E| E(var)3-95E| E(var)93E| H920_07105| I79_007483| M959_09551| MDA_GLEAN10022778| N300_14913| N301_10035| N302_02234| N303_01450| N305_05265| N307_12432| N309_03513| N311_05804| N320_08668| N325_07440| N326_06388| N330_10459| N331_09380| N335_05794| PAL_GLEAN10024239| PANDA_004504| PBR3| peroxisomal membrane protein 4, 24kDa| PRB-binding protein E2F-1| PXMP4| RBAP1| RBAP-1| RBBP3| RBBP-3| RBP3| retinoblastoma-associated protein 1| retinoblastoma-binding protein 3| transcription factor E2F1| TREES_T100008613| UY3_04541| xE2F| Y1Q_001163| Z169_05271| e2f1

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