Summary of E2F1
This gene encodes a protein that plays a role in the control of cell cycle. It also affects the action of tumor suppressor proteins (R).
The Function of E2F1
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812).
Protein names
Recommended name:
Transcription factor E2F1Short name:
PBR3Alternative name(s):
E2F-1Retinoblastoma-associated protein 1
RBAP-1
Retinoblastoma-binding protein 3
RBBP-3
pRB-binding protein E2F-1
- RS3213182 (E2F1) ??
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Top Gene-Substance Interactions
E2F1 Interacts with These Diseases
| Disease | Score |
Substances That Increase E2F1
| Substances | Interaction | Organism | Category |
Substances That Decrease E2F1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Enzyme Regulation:
BIRC2/c-IAP1 stimulates its transcriptional activity.
Molecular Function:
- Core Promoter Binding
- Dna Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Binding
- Sequence-Specific Dna Binding
Biological Processes:
- Dna Damage Checkpoint
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Transcription, Dna-Templated
- Regulation Of Transcription, Dna-Templated
- Dna Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
- Spermatogenesis
- Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage
- Positive Regulation Of Gene Expression
- Forebrain Development
- Anoikis
- Negative Regulation Of Dna Binding
- Negative Regulation Of Fat Cell Differentiation
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Fibroblast Proliferation
- Mrna Stabilization
- Negative Regulation Of Fat Cell Proliferation
- Cellular Response To Fatty Acid
- Cellular Response To Hypoxia
- Cellular Response To Xenobiotic Stimulus
- Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
- Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
- Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
- Lens Fiber Cell Apoptotic Process
- Cellular Response To Nerve Growth Factor Stimulus
- Regulation Of G1/S Transition Of Mitotic Cell Cycle