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  3. DUSP4

DUSP4 (Dual specificity phosphatase 4)

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The Function of DUSP4

Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.

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Protein names

Recommended name:

Dual specificity protein phosphatase 4

Short name:

MKP-2

Alternative name(s):

Dual specificity protein phosphatase hVH2
Mitogen-activated protein kinase phosphatase 2
MAP kinase phosphatase 2

Top Gene-Substance Interactions

Substances That Increase DUSP4

Substances Interaction Organism Category

Substances That Decrease DUSP4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • Nkx3-1 v1
  • Nkx3-1

Gene Pathways:

  • Immune System
  • MAPK signaling pathway
  • Signal Transduction
  • TRAF6 Mediated Induction of proinflammatory cytokines

Molecular Function:

  • Map Kinase Threonine Phosphatase Activity
  • Map Kinase Tyrosine/Serine/Threonine Phosphatase Activity
  • Phosphatase Activity
  • Protein Tyrosine/Threonine Phosphatase Activity
  • Protein Tyrosine Phosphatase Activity

Biological Processes:

  • Dephosphorylation
  • Endoderm Formation
  • Inactivation Of Mapk Activity
  • Negative Regulation Of Erk1 And Erk2 Cascade
  • Peptidyl-Threonine Dephosphorylation
  • Peptidyl-Tyrosine Dephosphorylation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| serine/threonine specific protein phosphatase| A306_10836| AS27_12806| AS28_13239| CB1_000944001| Dual specificity protein phosphatase 4| dual specificity protein phosphatase 4-like| dual specificity protein phosphatase hVH2| EGK_18816| EH28_21103| HVH2| M91_08548| M959_02773| MAP kinase phosphatase 2| MDA_GLEAN10024976| mitogen-activated protein kinase phosphatase 2| mkp-2| MKP2| N300_14940| N301_13151| N302_04291| N303_00910| N305_00517| N306_02826| N307_03779| N308_04484| N309_13534| N310_05121| N312_07395| N320_00559| N321_02942| N325_09679| N327_03861| N328_03563| N330_05276| N331_02064| N332_04784| N333_04231| N334_08469| N335_09349| N339_00795| PAL_GLEAN10021608| PANDA_018949| typ| VH1 homologous phosphatase 2| Y1Q_002241| Y956_01002| Z169_07563| dusp4

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