The Function of DUSP4
Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
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Protein names
Recommended name:
Dual specificity protein phosphatase 4Short name:
MKP-2Alternative name(s):
Dual specificity protein phosphatase hVH2Mitogen-activated protein kinase phosphatase 2
MAP kinase phosphatase 2
Top Gene-Substance Interactions
Substances That Increase DUSP4
| Substances | Interaction | Organism | Category |
Substances That Decrease DUSP4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Map Kinase Threonine Phosphatase Activity
- Map Kinase Tyrosine/Serine/Threonine Phosphatase Activity
- Phosphatase Activity
- Protein Tyrosine/Threonine Phosphatase Activity
- Protein Tyrosine Phosphatase Activity
Biological Processes:
- Dephosphorylation
- Endoderm Formation
- Inactivation Of Mapk Activity
- Negative Regulation Of Erk1 And Erk2 Cascade
- Peptidyl-Threonine Dephosphorylation
- Peptidyl-Tyrosine Dephosphorylation