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  3. DRD5

DRD5 (Dopamine receptor D5)

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Summary of DRD5

Dopamine receptor D5.

Plays a role in ADHD, the initiation of smoking, Parkinson's, Schizophrenia.

Activation of D5 receptors:

  • Increases BDNF in the prefrontal cortex.
  • Is concentrated in the limbic system
  • Found on Th cells
  • Increases Th17 cells, IL23
  • Lowers blood pressure
  • Reduces NK Cells and activity
  • Increases excretion of sodium
  • Increases learning and memory
  • Cause consolidation of fear memories in amygdala
  • Reduces amphetamine-induced activity
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Protein names

Recommended name:

D

Short name:

1B

Alternative name(s):

D(5
D1beta dopamine receptor
Dopamine D5 receptor

Top Gene-Substance Interactions

DRD5 Interacts with These Diseases

Disease Score

Substances That Increase DRD5

Substances Interaction Organism Category

Substances That Decrease DRD5

Substances Interaction Organism Category

Advanced Summary

Dopamine receptor D5 belongs to the D1-like receptor family.

D5 receptor is a subtype of the dopamine receptor that has a 10-fold higher affinity for dopamine than the D1 subtype.

The D5 subtype is a G-protein coupled receptor, which promotes synthesis of cAMP by adenylyl cyclase.

Activation of D5 receptors is shown to promote expression of BDNF in the prefrontal cortex.

D5 receptor is expressed more widely in the brain than dopamine receptor D1.

It is found in neurons in amygdala, frontal cortex, hippocampus, striatum, thalamus, hypothalamus, basal forebrain, cerebellum, and midbrain.

The receptors of this subtype are also expressed on dendritic cells and T helper cells.

D5 receptors are expressed in kidneys and are involved in regulation of sodium excretion. Their activation suppresses reabsorption of sodium . Their faulty functioning in nephrons can contribute to hypertension.

D5 receptor participates in the synaptic processes that underlie learning and memory. These receptors participate in the formation of LTD in rodent striatum, which is opposite to the D1 receptor involvement with the formation of LTP in the same brain region.

D5 receptors are also associated with the consolidation of fear memories in amygdala. It has been shown that M1-Muscarinic receptors cooperate with D5 receptors and beta-2 adrenergic receptors to consolidate cued fear memory.

D5 receptors may be required for long-term potentiation at the synapse between medial perforant path and dentate gyrus in murine hippocampal formation.

The dopamine receptor D5 has been suggested to play a role in the initiation of smoking. In a study on the association of four polymorphisms of this gene with smoking, a statistical analysis suggested that there may exist a haplotype of DRD5 that is protective against initiation of smoking.

The DRD5 gene is associated with ADHD in humans.  The long version of the gene was shown to be a protective factor against developing this disorder, while the short version was shown to be a risk factor for it.

Deficiency in D5receptors may contribute to learning problems that may be associated with ADHD.

Blockage of D5 receptors reduces burst firing in neurons and improves motor deficits in animal models.

Several polymorphisms in DRD5 genes have been associated with susceptibility to schizophrenia.

D5 receptor is believed to reduce amphetamine-induced activity.

D5 receptor may be involved in modulation of the neuronal pathways that regulate blood pressure. Mice lacking this receptor in their brains showed hypertension and elevated blood pressure, which may have been caused by increased sympathetic tone.

D5 receptors that are expressed in kidneys are also involved in the regulation of blood pressure via modulating expression of renalase and excretion of sodium, and disturbance of these processes can contribute to hypertension as well.

D5 receptors negatively regulate production of IFNγ by NK cells. The expression of D5 receptors was shown to be upregulated in NK cells in response to prolonged stimulation with recombinant interleukin 2. This upregulation inhibits proliferation of the NK cells and suppresses synthesis of IFNγ. Activation of D5 prevents p50, part of NF-κB protein complex, from repressing the transcription of miRNA 29a. Because miRNA29a targets mRNA of IFNγ, the expression of IFNγ protein is diminished.

D5 receptors are involved in activation and differentiation of T helper 17 cells. Specifically, these receptors play a role in polarization of CD4+ T-cells into the T helper 17 cells by modulating secretion of interleukin 12 and interleukin 23 in response to stimulation with LPS.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Sp1

Tissue specificity:

Neuron-specific, localized primarily within limbic regions of the brain.

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction
  • Calcium signaling pathway

Molecular Function:

  • Dopamine Binding
  • Dopamine Neurotransmitter Receptor Activity
  • Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs

Biological Processes:

  • Activation Of Adenylate Cyclase Activity
  • Adenylate Cyclase-Activating Dopamine Receptor Signaling Pathway
  • Adenylate Cyclase-Activating G-Protein Coupled Receptor Signaling Pathway
  • Associative Learning
  • Cellular Calcium Ion Homeostasis
  • Cellular Response To Catecholamine Stimulus
  • Chemical Synaptic Transmission
  • Learning
  • Long Term Synaptic Depression
  • Negative Regulation Of Blood Pressure
  • Negative Regulation Of Nad(P)H Oxidase Activity
  • Norepinephrine-Epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure
  • Phospholipase C-Activating Dopamine Receptor Signaling Pathway
  • Positive Regulation Of Adenylate Cyclase Activity
  • Positive Regulation Of Adenylate Cyclase Activity Involved In G-Protein Coupled Receptor Signaling Pathway
  • Reactive Oxygen Species Metabolic Process
  • Regulation Of Female Receptivity
  • Regulation Of Systemic Arterial Blood Pressure By Vasopressin
  • Response To Amphetamine
  • Response To Cocaine
  • Sensitization
  • Synaptic Transmission, Dopaminergic
  • Transmission Of Nerve Impulse
  • Wound Healing

Drug Bank:

  • Rotigotine
  • Zuclopenthixol
  • Bromocriptine
  • Cabergoline
  • Chlorpromazine
  • Cinnarizine
  • Dopamine
  • Ergotamine
  • Imipramine
  • Levodopa
  • Lisuride
  • Loxapine
  • Mianserin
  • Mirtazapine
  • Olanzapine
  • Pergolide
  • Pramipexole
  • Ropinirole
  • Trimipramine
  • Ziprasidone
  • Apomorphine
  • Aripiprazole
  • Fenoldopam
  • Methotrimeprazine
  • Quetiapine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS28_13163| Cytosolic carboxypeptidase 6| D1B| D(1B)| D1(B)| D1b dopamine receptor| D(1B) dopamine receptor| D1beta dopamine receptor| D5| D(5) dopamine receptor| D5 dopamine receptor| D5R| D623_10013410| DBDR| dopamine D1B receptor| dopamine D5 receptor| dopamine receptor 5| dopamine receptor D1(B)| Dopamine Receptor D1B| dopamine receptor type 1b| Drd1b| DRD1(B)| DRD1L2| Drd-5| Gpcr1| I79_002069| M959_03033| MDA_GLEAN10013852| N300_08546| N301_13438| N302_15064| N303_13339| N305_04503| N306_10373| N307_08653| N308_14084| N309_10684| N311_08936| N312_09218| N320_13170| N321_07971| N322_01341| N324_08842| N325_03858| N326_05710| N327_07602| N330_09086| N331_10847| N332_12469| N333_06349| N335_14535| N339_06329| N340_12383| PANDA_012455| TREES_T100005732| Y1Q_015667| Y956_04785| Z169_03868| drd5

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