Disease	Score

Substances	Interaction	Organism	Category

Substances	Interaction	Organism	Category

Dopamine receptor D5 belongs to the D1-like receptor family.

D5 receptor is a subtype of the dopamine receptor that has a 10-fold higher affinity for dopamine than the D1 subtype.

The D5 subtype is a G-protein coupled receptor, which promotes synthesis of cAMP by adenylyl cyclase.

Activation of D5 receptors is shown to promote expression of BDNF in the prefrontal cortex.

D5 receptor is expressed more widely in the brain than dopamine receptor D1.

It is found in neurons in amygdala, frontal cortex, hippocampus, striatum, thalamus, hypothalamus, basal forebrain, cerebellum, and midbrain.

The receptors of this subtype are also expressed on dendritic cells and T helper cells.

D5 receptors are expressed in kidneys and are involved in regulation of sodium excretion. Their activation suppresses reabsorption of sodium . Their faulty functioning in nephrons can contribute to hypertension.

D5 receptor participates in the synaptic processes that underlie learning and memory. These receptors participate in the formation of LTD in rodent striatum, which is opposite to the D1 receptor involvement with the formation of LTP in the same brain region.

D5 receptors are also associated with the consolidation of fear memories in amygdala. It has been shown that M1-Muscarinic receptors cooperate with D5 receptors and beta-2 adrenergic receptors to consolidate cued fear memory.

D5 receptors may be required for long-term potentiation at the synapse between medial perforant path and dentate gyrus in murine hippocampal formation.

The dopamine receptor D5 has been suggested to play a role in the initiation of smoking. In a study on the association of four polymorphisms of this gene with smoking, a statistical analysis suggested that there may exist a haplotype of DRD5 that is protective against initiation of smoking.

The DRD5 gene is associated with ADHD in humans.  The long version of the gene was shown to be a protective factor against developing this disorder, while the short version was shown to be a risk factor for it.

Deficiency in D5receptors may contribute to learning problems that may be associated with ADHD.

Blockage of D5 receptors reduces burst firing in neurons and improves motor deficits in animal models.

Several polymorphisms in DRD5 genes have been associated with susceptibility to schizophrenia.

D5 receptor is believed to reduce amphetamine-induced activity.

D5 receptor may be involved in modulation of the neuronal pathways that regulate blood pressure. Mice lacking this receptor in their brains showed hypertension and elevated blood pressure, which may have been caused by increased sympathetic tone.

D5 receptors that are expressed in kidneys are also involved in the regulation of blood pressure via modulating expression of renalase and excretion of sodium, and disturbance of these processes can contribute to hypertension as well.

D5 receptors negatively regulate production of IFNγ by NK cells. The expression of D5 receptors was shown to be upregulated in NK cells in response to prolonged stimulation with recombinant interleukin 2. This upregulation inhibits proliferation of the NK cells and suppresses synthesis of IFNγ. Activation of D5 prevents p50, part of NF-κB protein complex, from repressing the transcription of miRNA 29a. Because miRNA29a targets mRNA of IFNγ, the expression of IFNγ protein is diminished.

D5 receptors are involved in activation and differentiation of T helper 17 cells. Specifically, these receptors play a role in polarization of CD4+ T-cells into the T helper 17 cells by modulating secretion of interleukin 12 and interleukin 23 in response to stimulation with LPS.

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

The following transcription factors affect gene expression:

• Sp1

Tissue specificity:

Neuron-specific, localized primarily within limbic regions of the brain.

Molecular Function:

• Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs
• Dopamine Neurotransmitter Receptor Activity
• Dopamine Binding

Biological Processes:

• Synaptic Transmission, Dopaminergic
• Response To Amphetamine
• Regulation Of Systemic Arterial Blood Pressure By Vasopressin
• Norepinephrine-Epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure
• Cellular Calcium Ion Homeostasis
• Adenylate Cyclase-Activating G-Protein Coupled Receptor Signaling Pathway
• Activation Of Adenylate Cyclase Activity
• Adenylate Cyclase-Activating Dopamine Receptor Signaling Pathway
• Chemical Synaptic Transmission
• Learning
• Associative Learning
• Positive Regulation Of Adenylate Cyclase Activity Involved In G-Protein Coupled Receptor Signaling Pathway
• Transmission Of Nerve Impulse
• Negative Regulation Of Nad(P)H Oxidase Activity
• Wound Healing
• Response To Cocaine
• Positive Regulation Of Adenylate Cyclase Activity
• Negative Regulation Of Blood Pressure
• Regulation Of Female Receptivity
• Sensitization
• Phospholipase C-Activating Dopamine Receptor Signaling Pathway
• Long Term Synaptic Depression
• Cellular Response To Catecholamine Stimulus
• Reactive Oxygen Species Metabolic Process

Drug Bank:

• Rotigotine
• Zuclopenthixol
• Bromocriptine
• Cabergoline
• Chlorpromazine
• Cinnarizine
• Dopamine
• Ergotamine
• Imipramine
• Levodopa
• Lisuride
• Loxapine
• Mianserin
• Mirtazapine
• Olanzapine
• Pergolide
• Pramipexole
• Ropinirole
• Trimipramine
• Ziprasidone
• Apomorphine
• Aripiprazole
• Fenoldopam
• Methotrimeprazine
• Quetiapine

*synonyms