The Function of DOK3
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function.
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Protein names
Recommended name:
Docking protein 3Alternative name(s):
Downstream of tyrosine kinase 3Top Gene-Substance Interactions
DOK3 Interacts with These Diseases
| Disease | Score |
Substances That Increase DOK3
| Substances | Interaction | Organism | Category |
Substances That Decrease DOK3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in spleen.