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  3. DOK2

DOK2 (Docking protein 2)

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The Function of DOK2

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation.

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Protein names

Recommended name:

Docking protein 2

Alternative name(s):

Downstream of tyrosine kinase 2
p56(dok-2

Top Gene-Substance Interactions

DOK2 Interacts with These Diseases

Disease Score

Substances That Increase DOK2

Substances Interaction Organism Category

Substances That Decrease DOK2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1

Tissue specificity:

Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver.

Gene Pathways:

  • Hemostasis

Molecular Function:

  • Signal Transducer Activity, Downstream Of Receptor

Biological Processes:

  • Cell Surface Receptor Signaling Pathway
  • Leukocyte Migration
  • Ras Protein Signal Transduction
  • Signal Transduction
  • Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_10632| AS27_03588| CB1_000471019| docking protein 2, 56kD| docking protein 2, 56kDa| Dok-2| dok-R| DokR| dok-related protein| Downstream of tyrosine kinase 2| Frip| GW7_20716| IL-four receptor-interacting protein| IL-Four Receptor Interacting Protein| M91_04190| N303_05414| N321_08167| N326_04973| p56DOK| p56(dok-2)| p56dok-2| PAL_GLEAN10006753| PANDA_002776| TREES_T100017931| Y1Q_016889| Y956_10054| dok2

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