The Function of DOK2
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation.
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Protein names
Recommended name:
Docking protein 2Alternative name(s):
Downstream of tyrosine kinase 2p56(dok-2
Top Gene-Substance Interactions
DOK2 Interacts with These Diseases
| Disease | Score |
Substances That Increase DOK2
| Substances | Interaction | Organism | Category |
Substances That Decrease DOK2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver.
Gene Pathways:
Molecular Function:
Biological Processes:
- Cell Surface Receptor Signaling Pathway
- Leukocyte Migration
- Ras Protein Signal Transduction
- Signal Transduction
- Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway