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  3. DNAJC10

DNAJC10 (DnaJ heat shock protein family (Hsp40) member C10)

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The Function of DNAJC10

Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.

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Protein names

Recommended name:

DnaJ homolog subfamily C member 10

Alternative name(s):

Endoplasmic reticulum DNA J domain-containing protein 5
ER-resident protein ERdj5
ERdj5
Macrothioredoxin
MTHr

Top Gene-Substance Interactions

DNAJC10 Interacts with These Diseases

Disease Score

Substances That Increase DNAJC10

Substances Interaction Organism Category

Substances That Decrease DNAJC10

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1
  • HNF-1A
  • HNF-1
  • XBP-1
  • ATF6
  • NCX/Ncx

Gene Pathways:

  • Protein processing in endoplasmic reticulum

Induction:

By endoplasmic reticulum stress.

Molecular Function:

  • Atpase Activator Activity
  • Atpase Binding
  • Chaperone Binding
  • Disulfide Oxidoreductase Activity
  • Hsp70 Protein Binding
  • Misfolded Protein Binding
  • Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, Disulfide As Acceptor
  • Protein Disulfide Oxidoreductase Activity

Biological Processes:

  • Cell Redox Homeostasis
  • Er-Associated Ubiquitin-Dependent Protein Catabolic Process
  • Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
  • Negative Regulation Of Protein Phosphorylation
  • Positive Regulation Of Atpase Activity
  • Protein Folding In Endoplasmic Reticulum
  • Response To Endoplasmic Reticulum Stress
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_02006| AS27_10586| AS28_03299| CB1_001170004| D2Ertd706e| D623_10035046| DnaJ homolog| dnaJ homolog subfamily C member 10| DnaJ (Hsp40) homolog, subfamily C, member 10| DnaJ (Hsp40)-like protein, subfamily C, member 10| DnaJ like protein subfamily C member 10| DnaJ-like protein subfamily C member 10| DnaJ-like protein subfamily C member 10-like protein| dnaJ-like subfamily C member 10| DnaJ subfamily C member 10| endoplasmic reticulum DNA J domain-containing protein 5| endoplasmic reticulum DnaJ-PDI fusion protein 1| Erdj5| ER-resident protein ERdj5| GW7_10932| H920_10617| Hsp40| j domain-containing PDI-like protein| j domain-containing protein disulfide isomerase-like protein| J-domain-containing protein disulfide isomerase-like protein| JPDI| M91_06999| M959_07245| macrothioredoxin| MDA_GLEAN10026184| MTHr| N300_08683| N301_14183| N302_06698| N303_08452| N305_06681| N306_04957| N307_04190| N308_10152| N309_08241| N310_05104| N311_12153| N312_11884| N320_12166| N321_04634| N322_06858| N324_00975| N326_05937| N327_08580| N328_08652| N329_05176| N330_10237| N331_06233| N332_10033| N333_07870| N334_02668| N336_11144| N340_05269| N341_12079| PANDA_018423| PDIA19| protein disulfide isomerase family A, member 19| UY3_16551| Y1Q_015429| Y956_07578| Z169_11484| dnajc10

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