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DMBT1 (Deleted in malignant brain tumors 1)

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Summary of DMBT1

This gene might be a tumor suppressor gene and helps in the immune system response (R).

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The Function of DMBT1

May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell.

Protein names

Recommended name:

Deleted in malignant brain tumors 1 protein

Short name:

SAG

Alternative name(s):

Glycoprotein 340
Gp-340
Hensin
Salivary agglutinin
Surfactant pulmonary-associated D-binding protein

DMBT1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11523871 (DMBT1) ??
  2. RS2981745 (DMBT1) ??
  3. RS3013236 (DMBT1) ??

Top Gene-Substance Interactions

DMBT1 Interacts with These Diseases

Disease Score

Substances That Increase DMBT1

Substances Interaction Organism Category

Substances That Decrease DMBT1

Substances Interaction Organism Category

Advanced Summary

     From UniProt: Glioma (GLM): Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. [MIM:137800]

     From NCBI Gene: Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. This gene was originally isolated based on its deletion in a medulloblastoma cell line. This gene is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The encoded protein precursor is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Mar 2016] From UniProt: May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • CUTL1
  • p53
  • NF-kappaB1

Tissue specificity:

Highly expressed in alveolar and macrophage tissues. In some macrophages, expression is seen on the membrane, and in other macrophages, strongly expressed in the phagosome/phagolysosome compartments. Expressed in lung, trachea, salivary gland, small intestine and stomach. In pancreas, expressed in certain cells of the islets of Langerhans. In digestive tract, confined to tissues with large epithelial surfaces. In intestinal tissue, moderately expressed in epithelial cells of the midcrypts and the crypt base. Expression is significantly elevated in intestinal tissue from patients with inflammatory bowel disease (IBD), particularly in surface epithelial and Paneth cells, but not in IBD patients with mutant NOD2. Present in crypt bases of the duodenum, in crypt tops of the colon, and in collecting ducts of the cortical kidney. Expressed in stratified squamous epithelium of vagina and in outer luminar surface and basilar region of columnar epithelial cells in cervix (at protein level). Isoform 1 is secreted to the lumen of the respiratory tract.

Gene Pathways:

  • Salivary secretion

Induction:

Up-regulated in intestinal epithelial cells in response to proinflammatory stimuli including TNF and bacterial lipopolysaccharides (LPS).

Developmental stage:

Expressed in fetal lung, intestine and skin. Secreted to the extracellular matrix (ECM) in certain fetal epithelia.

Molecular Function:

  • Calcium-Dependent Protein Binding
  • Scavenger Receptor Activity
  • Signaling Pattern Recognition Receptor Activity
  • Zymogen Binding

Biological Processes:

  • Cellular Protein Metabolic Process
  • Defense Response To Virus
  • Epithelial Cell Differentiation
  • Induction Of Bacterial Agglutination
  • Innate Immune Response
  • Multicellular Organism Development
  • Protein Transport
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Deleted in malignant brain tumors 1 protein| p80| apactin| AS27_02826| CB1_100174004| CRP| CRP-[a]| CRP-[b]| Crpd| crp-ductin| DBMT1| deleted in malignant brain tumors 1 protein-like| deleted in malignant brain tumors 1 pseudogene| ebnerin| gall-bladder mucin| glycoprotein 300| glycoprotein 340| gp300| gp340| gp-340| H920_08952| hensin| I79_020975| M91_16346| M959_12107| MDA_GLEAN10006692| MUCIN| mucin-like glycoprotein| muclin| N300_08976| N302_11673| N303_11657| N307_06007| N310_05997| N312_08904| N324_02669| N335_04454| pancrin| PANDA_021747| SAG| salivary agglutinin| SALSA| surfactant pulmonary-associated D-binding protein| tmem52b| transmembrane protein 52B| UY3_11171| vomeroglandin| Z169_03843| dmbt1

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