Substances	Interaction	Organism	Category

Substances	Interaction	Organism	Category

     From NCBI Gene: Tricho-dento-osseous syndromeAmelogenesis imperfecta, type IVFrom UniProt: Trichodentoosseous syndrome (TDO): An autosomal dominant disease characterized by curly kinky hair at birth, enamel hypoplasia, taurodontism, thickening of cortical bones and variable expression of craniofacial morphology. [MIM:190320] Amelogenesis imperfecta 4 (AI4): An autosomal dominant defect of enamel formation associated with enlarged pulp chambers. Enamel is thin, teeth are small and widely spaced. [MIM:104510]

     From NCBI Gene: Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. [provided by RefSeq, Jul 2008] From UniProt: Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

The following transcription factors affect gene expression:

• C/EBPbeta
• C/EBPalpha
• Sox9
• Msx-1

Molecular Function:

• Chromatin Binding
• Sequence-Specific Dna Binding
• Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
• Transcription Factor Activity, Sequence-Specific Dna Binding

Biological Processes:

• Blood Vessel Development
• Odontoblast Differentiation
• Odontogenesis Of Dentin-Containing Tooth
• Placenta Development

*synonyms