The Function of DHRS3
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
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Protein names
Recommended name:
Short-chain dehydrogenase/reductase 3Short name:
DD83.1Alternative name(s):
Retinal short-chain dehydrogenase/reductase 1retSDR1
Retinol dehydrogenase 17
Short chain dehydrogenase/reductase family 16C member 1
- RS3924048 (DHRS3) ??
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Top Gene-Substance Interactions
Substances That Increase DHRS3
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Substances That Decrease DHRS3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain. In the retina, expressed in cone but not rod outer segments.
Gene Pathways:
Induction:
By retinoic acid.
Molecular Function:
- Nucleotide Binding
- Retinol Dehydrogenase Activity
- Electron Carrier Activity
- Nadp-Retinol Dehydrogenase Activity
Biological Processes:
- Retinoid Metabolic Process
- Outflow Tract Morphogenesis
- Visual Perception
- Regulation Of Ossification
- Retinol Metabolic Process
- Negative Regulation Of Retinoic Acid Receptor Signaling Pathway
- Palate Development
- Bone Morphogenesis
- Cardiac Septum Morphogenesis