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  3. DHRS3

DHRS3 (Dehydrogenase/reductase 3)

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The Function of DHRS3

Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.

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Protein names

Recommended name:

Short-chain dehydrogenase/reductase 3

Short name:

DD83.1

Alternative name(s):

Retinal short-chain dehydrogenase/reductase 1
retSDR1
Retinol dehydrogenase 17
Short chain dehydrogenase/reductase family 16C member 1

DHRS3 SNPs

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  1. RS3924048 (DHRS3) ??

Top Gene-Substance Interactions

Substances That Increase DHRS3

Substances Interaction Organism Category

Substances That Decrease DHRS3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

Tissue specificity:

Widely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain. In the retina, expressed in cone but not rod outer segments.

Gene Pathways:

  • Metabolic pathways
  • Disease
  • Signal Transduction
  • Retinol metabolism

Induction:

By retinoic acid.

Molecular Function:

  • Electron Carrier Activity
  • Nadp-Retinol Dehydrogenase Activity
  • Nucleotide Binding
  • Retinol Dehydrogenase Activity

Biological Processes:

  • Bone Morphogenesis
  • Cardiac Septum Morphogenesis
  • Negative Regulation Of Retinoic Acid Receptor Signaling Pathway
  • Outflow Tract Morphogenesis
  • Palate Development
  • Regulation Of Ossification
  • Retinoid Metabolic Process
  • Retinol Metabolic Process
  • Visual Perception

Drug Bank:

  • Vitamin A
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_03395| AS27_12967| AS28_08751| CB1_001783012| D623_10022035| DD83.1| dehydrogenase/reductase member 3| dehydrogenase/reductase (SDR family) member 3| EGK_00247| GW7_09087| H920_07001| I79_019338| M959_03285| MDA_GLEAN10024354| N300_01448| N302_09967| N303_02606| N306_05307| N307_01420| N308_08279| N309_10635| N310_01566| N311_04729| N312_04543| N320_09638| N321_01622| N322_08465| N324_09831| N325_02202| N326_12840| N327_12036| N328_09937| N329_09391| N330_05083| N331_08011| N332_05513| N333_04104| N334_10506| N335_03406| N336_10395| N339_04236| N340_04023| N341_08674| PAL_GLEAN10012974| PANDA_015162| RDH17| retinal dehydrogenase/reductase family member 3| retinal short-chain dehydrogenase/reductase 1| retinol dehydrogenase 17| retSDR1| Rsdr1| SDR1| SDR16C1| short-chain dehydrogenase/reductase 1| Short-chain dehydrogenase/reductase 3| short chain dehydrogenase/reductase family 16C member 1| TREES_T100008873| UY3_01215| Y1Q_012022| Y956_10759| Z169_14435| dhrs3

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