The Function of DGAT2
Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT).
Protein names
Recommended name:
Diacylglycerol O-acyltransferase 2Short name:
ARATAlternative name(s):
Acyl-CoA retinol O-fatty-acyltransferaseRetinol O-fatty-acyltransferase
Diglyceride acyltransferase 2
Top Gene-Substance Interactions
DGAT2 Interacts with These Diseases
| Disease | Score |
Substances That Increase DGAT2
| Substances | Interaction | Organism | Category |
Substances That Decrease DGAT2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin.
Enzyme Regulation:
Inhibited by niacin.
Molecular Function:
- 2-Acylglycerol O-Acyltransferase Activity
- Diacylglycerol O-Acyltransferase Activity
- Protein Homodimerization Activity
- Retinol O-Fatty-Acyltransferase Activity
Biological Processes:
- Acylglycerol Acyl-Chain Remodeling
- Cellular Response To Oleic Acid
- Cellular Triglyceride Homeostasis
- Cholesterol Homeostasis
- Diacylglycerol Metabolic Process
- Fat Pad Development
- Fatty Acid Homeostasis
- Glycerol Metabolic Process
- Lipid Storage
- Long-Chain Fatty-Acyl-Coa Metabolic Process
- Low-Density Lipoprotein Particle Clearance
- Negative Regulation Of Fatty Acid Oxidation
- Positive Regulation Of Gluconeogenesis
- Positive Regulation Of Triglyceride Biosynthetic Process
- Regulation Of Cholesterol Metabolic Process
- Regulation Of Lipoprotein Metabolic Process
- Regulation Of Plasma Lipoprotein Particle Levels
- Triglyceride Biosynthetic Process