Summary of DERL3
derl3 encodes a protein used to degrade misfolded glyco-proteins in the endoplasmic reticulum (ER). [R]
The Function of DERL3
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate.
Protein names
Recommended name:
Derlin-3Alternative name(s):
Degradation in endoplasmic reticulum protein 3DERtrin-3
Der1-like protein 3
- RS1128127 (DERL3) ??
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Top Gene-Substance Interactions
Substances That Increase DERL3
| Substances | Interaction | Organism | Category |
Substances That Decrease DERL3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Unlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta, pancreas, spleen and small intestine.
Induction:
Up-regulated in response to endoplasmic reticulum stress via the ERN1-XBP1 pathway of the unfolded protein response (UPR).
Biological Processes:
- Endoplasmic Reticulum Unfolded Protein Response
- Er-Associated Ubiquitin-Dependent Protein Catabolic Process
- Negative Regulation Of Retrograde Protein Transport, Er To Cytosol
- Protein N-Linked Glycosylation Via Asparagine