The Function of DERL2
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation.
Protein names
Recommended name:
Derlin-2Alternative name(s):
Degradation in endoplasmic reticulum protein 2DERtrin-2
Der1-like protein 2
F-LAN-1
F-LANa
Top Gene-Substance Interactions
Substances That Increase DERL2
| Substances | Interaction | Organism | Category |
Substances That Decrease DERL2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitous. Overexpressed in various hepatocarcinomas.
Induction:
Up-regulated in response to endoplasmic reticulum stress via the ERN1-XBP1 pathway of the unfolded protein response (UPR).
Biological Processes:
- Endoplasmic Reticulum Mannose Trimming
- Endoplasmic Reticulum Unfolded Protein Response
- Er-Associated Ubiquitin-Dependent Protein Catabolic Process
- Negative Regulation Of Retrograde Protein Transport, Er To Cytosol
- Positive Regulation Of Cell Growth
- Positive Regulation Of Cell Proliferation
- Retrograde Protein Transport, Er To Cytosol
- Suckling Behavior