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  3. DCLK1

DCLK1 (Doublecortin like kinase 1)

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Summary of DCLK1

This gene encodes a protein that binds microtubules and regulate microtubule polymerization, looks over protein-protein interaction, and is involved in memory and brain processes (R).

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The Function of DCLK1

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.

Protein names

Recommended name:

Serine/threonine-protein kinase DCLK1

Alternative name(s):

Doublecortin domain-containing protein 3A
Doublecortin-like and CAM kinase-like 1
Doublecortin-like kinase 1

DCLK1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12428086 (DCLK1) ??
  2. RS1926320 (DCLK1) ??
  3. RS2051090 (DCLK1) ??
  4. RS34065801 (DCLK1) ??
  5. RS6563210 (DCLK1) ??
  6. RS7328278 (DCLK1) ??
  7. RS9315385 (DCLK1) ??
  8. RS9546434 (DCLK1) ??

Top Gene-Substance Interactions

Substances That Increase DCLK1

Substances Interaction Organism Category

Substances That Decrease DCLK1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AhR
  • Arnt
  • NF-kappaB1
  • c-Rel
  • Bach1
  • NF-kappaB2
  • RelA

Tissue specificity:

In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain.

Induction:

Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).

Molecular Function:

  • Atp Binding
  • Protein Serine/Threonine Kinase Activity
  • Signal Transducer Activity, Downstream Of Receptor

Biological Processes:

  • Axon Extension
  • Central Nervous System Development
  • Central Nervous System Projection Neuron Axonogenesis
  • Dendrite Morphogenesis
  • Endosomal Transport
  • Forebrain Development
  • Intracellular Signal Transduction
  • Negative Regulation Of Protein Localization To Nucleus
  • Nervous System Development
  • Neuron Migration
  • Peptidyl-Serine Phosphorylation
  • Protein Phosphorylation
  • Response To Virus
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| CL1| dclk1| doublecortin and calcium/calmodulin-dependent protein kinase-like 1| doublecortin and CaM kinase-like 1| doublecortin-like kinase 1| A306_11579| Ania4| AS27_03096| AS28_02363| CB1_000622028| CLICK1| Click-I| CLICK-I beta| Cpg16| D623_10026647| DCAMKL1| DCDC3A| Dcl| DCLK| DCLK2| double cortin and calcium/calmodulin-dependent protein kinase-like 1| doublecortin domain-containing protein 3A| doublecortin-like and CAM kinase-like 1| doublecortin-like kinase 2| H920_05274| I79_009648| M91_09249| M959_00658| MDA_GLEAN10002595| N300_05201| N301_03006| N302_00876| N303_10192| N305_04440| N306_02315| N307_09655| N308_01799| N309_06625| N311_03747| N320_12309| N321_08492| N325_01134| N326_01010| N327_10144| N329_05949| N332_05082| N335_14122| N336_07395| N339_04791| N341_03124| PAL_GLEAN10010626| PANDA_012647| Serine/threonine-protein kinase DCLK1| SOHLH2| spermatogenesis and oogenesis specific basic helix-loop-helix 2| TREES_T100014338| UY3_17623| Y1Q_006023| Y956_16053| Z169_09809

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