Summary of DCLK1
This gene encodes a protein that binds microtubules and regulate microtubule polymerization, looks over protein-protein interaction, and is involved in memory and brain processes (R).
The Function of DCLK1
Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
Protein names
Recommended name:
Serine/threonine-protein kinase DCLK1Alternative name(s):
Doublecortin domain-containing protein 3ADoublecortin-like and CAM kinase-like 1
Doublecortin-like kinase 1
- RS12428086 (DCLK1) ??
- RS1926320 (DCLK1) ??
- RS2051090 (DCLK1) ??
- RS34065801 (DCLK1) ??
- RS6563210 (DCLK1) ??
- RS7328278 (DCLK1) ??
- RS9315385 (DCLK1) ??
- RS9546434 (DCLK1) ??
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Top Gene-Substance Interactions
Substances That Increase DCLK1
| Substances | Interaction | Organism | Category |
Substances That Decrease DCLK1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain.
Induction:
Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).
Molecular Function:
- Protein Serine/Threonine Kinase Activity
- Signal Transducer Activity, Downstream Of Receptor
- Atp Binding
Biological Processes:
- Neuron Migration
- Protein Phosphorylation
- Nervous System Development
- Central Nervous System Development
- Response To Virus
- Endosomal Transport
- Peptidyl-Serine Phosphorylation
- Central Nervous System Projection Neuron Axonogenesis
- Forebrain Development
- Intracellular Signal Transduction
- Axon Extension
- Dendrite Morphogenesis
- Negative Regulation Of Protein Localization To Nucleus