• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. DBH

DBH (Dopamine beta-hydroxylase)

Loading...

Summary of DBH

DBH encodes a protein that converts dopamine to norepinephrine (R). 

Low DBH might cause neuoticism, impulsitiviy, and aggression (R, R, R). It is also associated with schizophrenia (R). 

0 users want this gene increased, 0 users want it decreased

The Function of DBH

Conversion of dopamine to noradrenaline.

Protein names

Recommended name:

Dopamine beta-hydroxylase

Alternative name(s):

Dopamine beta-monooxygenase

DBH SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1108580 (DBH) ??
  2. RS1611115 (DBH) ??
  3. RS2519152 (DBH) ??
  4. RS3025343 (DBH) ??
  5. RS4531 (DBH) ??
  6. RS77905 (DBH) ??

Top Gene-Substance Interactions

DBH Interacts with These Diseases

Disease Score

Fixes

Fix: Vitamin C (required as a cofactor) (R) Adrenal glandular,

Substances That Increase DBH

Substances Interaction Organism Category

Substances That Decrease DBH

Substances Interaction Organism Category

Advanced Summary

For rs1611115, T = higher dopamine and lower norephinephrine because of lower DBH (Dopamine-beta-hydroxylase), which converts dopamine to norepinephrine (R). TT=

  • more neuroticism (R),
  • more novelty seeking (R),
  • more impulsivity (R),
  • more aggression (R),
  • adult ADHD (R),
  • lower conscientiousness (R),

     dopamine beta-hydroxylase deficiency At least six mutations in the DBH gene have been found to cause dopamine β-hydroxylase deficiency. The most common mutation (usually written as IVS1+2T>C) interferes with the normal processing of dopamine β-hydroxylase. As a result of this mutation, an abnormally short, nonfunctional version of the enzyme is produced. A lack of functional dopamine β-hydroxylase leads to a shortage of norepinephrine, which causes difficulty with regulating blood pressure and other autonomic nervous system problems seen in dopamine β-hydroxylase deficiency. other disorders Studies have shown certain variations (polymorphisms) in the DBH gene to be associated with increased risk of attention deficit hyperactivity disorder (ADHD). DBH gene polymorphisms are also thought to increase the risk of psychotic symptoms in people with schizophrenia or unipolar major depression. Other studies, however, have not supported these findings. Many genetic and environmental factors are believed to contribute to these complex conditions.

     The DBH gene provides instructions for producing the enzyme dopamine beta (β)-hydroxylase. This enzyme converts dopamine to norepinephrine, both of which are chemical messengers (neurotransmitters) that transmit signals between nerve cells. Norepinephrine plays an important role in the autonomic nervous system, which controls involuntary body processes such as the regulation of blood pressure and body temperature.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Tyrosine metabolism

Induction:

Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids.

Cofactor:

Binds 2 copper ions per subunit.

Molecular Function:

  • Catalytic Activity
  • Copper Ion Binding
  • Dopamine Beta-Monooxygenase Activity
  • L-Ascorbic Acid Binding

Biological Processes:

  • Behavioral Response To Ethanol
  • Blood Vessel Remodeling
  • Catecholamine Biosynthetic Process
  • Chemical Synaptic Transmission
  • Cytokine Production
  • Dopamine Catabolic Process
  • Fear Response
  • Glucose Homeostasis
  • Homoiothermy
  • Leukocyte Mediated Immunity
  • Leukocyte Migration
  • Locomotory Behavior
  • Maternal Behavior
  • Memory
  • Norepinephrine Biosynthetic Process
  • Octopamine Biosynthetic Process
  • Positive Regulation Of Vasoconstriction
  • Regulation Of Cell Proliferation
  • Regulation Of Extrinsic Apoptotic Signaling Pathway
  • Response To Amphetamine
  • Response To Pain
  • Visual Learning

Drug Bank:

  • Vitamin C
  • Disulfiram
  • Dopamine
  • Propylthiouracil
  • Capsaicin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_01658| AS28_01105| CB1_000453004| DBM| dopamine beta hydroxylase| dopamine-beta-hydroxylase| dopamine beta-hydroxylase (dopamine beta-monooxygenase)| Dopamine beta hydroxylase (dopamine beta-monooxygenase)| dopamine beta-monooxygenase| DOPBHY| H920_17157| M91_19677| M959_09357| N301_12457| N302_13087| N303_06181| N305_12820| N306_14724| N307_02526| N308_09231| N311_05544| N320_01833| N321_08666| N322_03683| N324_01328| N326_04529| N327_07697| N328_06641| N329_13154| N330_01742| N331_04138| N332_10387| N333_05125| N334_04308| N335_05529| N336_03576| N339_11867| N340_01630| N341_05180| PAL_GLEAN10012629| PANDA_009520| Tbh| TREES_T100016411| UY3_08213| Y1Q_015543| Z169_10154| dbh

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved