Disease	Score

Substances	Interaction	Organism	Category

Substances	Interaction	Organism	Category

For rs1611115, T = higher dopamine and lower norephinephrine because of lower DBH (Dopamine-beta-hydroxylase), which converts dopamine to norepinephrine (R). TT=

• more neuroticism (R),
• more novelty seeking (R),
• more impulsivity (R),
• more aggression (R),
• adult ADHD (R),
• lower conscientiousness (R),

     dopamine beta-hydroxylase deficiency At least six mutations in the DBH gene have been found to cause dopamine β-hydroxylase deficiency. The most common mutation (usually written as IVS1+2T>C) interferes with the normal processing of dopamine β-hydroxylase. As a result of this mutation, an abnormally short, nonfunctional version of the enzyme is produced. A lack of functional dopamine β-hydroxylase leads to a shortage of norepinephrine, which causes difficulty with regulating blood pressure and other autonomic nervous system problems seen in dopamine β-hydroxylase deficiency. other disorders Studies have shown certain variations (polymorphisms) in the DBH gene to be associated with increased risk of attention deficit hyperactivity disorder (ADHD). DBH gene polymorphisms are also thought to increase the risk of psychotic symptoms in people with schizophrenia or unipolar major depression. Other studies, however, have not supported these findings. Many genetic and environmental factors are believed to contribute to these complex conditions.

     The DBH gene provides instructions for producing the enzyme dopamine beta (β)-hydroxylase. This enzyme converts dopamine to norepinephrine, both of which are chemical messengers (neurotransmitters) that transmit signals between nerve cells. Norepinephrine plays an important role in the autonomic nervous system, which controls involuntary body processes such as the regulation of blood pressure and body temperature.

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

The following transcription factors affect gene expression:

• GR
• GR-alpha
• GR-beta

Induction:

Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids.

Cofactor:

Binds 2 copper ions per subunit.

Molecular Function:

• Catalytic Activity
• Copper Ion Binding
• Dopamine Beta-Monooxygenase Activity
• L-Ascorbic Acid Binding

Biological Processes:

• Behavioral Response To Ethanol
• Blood Vessel Remodeling
• Catecholamine Biosynthetic Process
• Chemical Synaptic Transmission
• Cytokine Production
• Dopamine Catabolic Process
• Fear Response
• Glucose Homeostasis
• Homoiothermy
• Leukocyte Mediated Immunity
• Leukocyte Migration
• Locomotory Behavior
• Maternal Behavior
• Memory
• Norepinephrine Biosynthetic Process
• Octopamine Biosynthetic Process
• Positive Regulation Of Vasoconstriction
• Regulation Of Cell Proliferation
• Regulation Of Extrinsic Apoptotic Signaling Pathway
• Response To Amphetamine
• Response To Pain
• Visual Learning

Drug Bank:

• Vitamin C
• Disulfiram
• Dopamine
• Propylthiouracil
• Capsaicin

*synonyms