Summary of DAPK1
This gene encodes a protein that is involved in multiple cellular signaling pathways that trigger cell survival and programmed cell death (R).
The Function of DAPK1
Isoform 2 cannot induce apoptosis but can induce membrane blebbing.
Protein names
Recommended name:
Death-associated protein kinase 1Alternative name(s):
DAP kinase 1- RS11141915 (DAPK1) ??
- RS1421001 (DAPK1) ??
- RS1806864 (DAPK1) ??
- RS3095748 (DAPK1) ??
- RS3118867 (DAPK1) ??
- RS4877365 (DAPK1) ??
- RS4878104 (DAPK1) ??
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Top Gene-Substance Interactions
DAPK1 Interacts with These Diseases
| Disease | Score |
Substances That Increase DAPK1
| Substances | Interaction | Organism | Category |
Substances That Decrease DAPK1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 2 is expressed in normal intestinal tissue as well as in colorectal carcinomas.
Gene Pathways:
Induction:
Up-regulated following treatment with IFNG/IFN-gamma.
Enzyme Regulation:
Activated by Ca(2+)/calmodulin. Regulated by a locking mechanism, involving autophosphorylation at Ser-308 and calmodulin binding. In the inactive state, Ser-308 is phosphorylated. Activation involves its dephosphorylation and a release-of-autoinhibition mechanism where binding of calmodulin induces a conformational change that relieves the steric block of the active site by the autoinhibitory domain. Activity is modulated by UNC5B and NTN1. UNC5B activates it by inhibiting the phosphorylation at Ser-308, whereas NTN1 inhibits UNC5B-mediated activation of DAPK1. Endoplasmic-stress activates by causing Ser-308 dephosphorylation.
Molecular Function:
- Protein Serine/Threonine Kinase Activity
- Calmodulin-Dependent Protein Kinase Activity
- Calmodulin Binding
- Atp Binding
- Gtp Binding
- Syntaxin-1 Binding
- Identical Protein Binding
Biological Processes:
- Protein Phosphorylation
- Apoptotic Process
- Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
- Regulation Of Autophagy
- Negative Regulation Of Translation
- Intracellular Signal Transduction
- Regulation Of Apoptotic Process
- Positive Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Protein Autophosphorylation
- Cellular Response To Interferon-Gamma
- Apoptotic Signaling Pathway
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
- Regulation Of N-Methyl-D-Aspartate Selective Glutamate Receptor Activity