Disease	Score

Substances	Interaction	Organism	Category

Substances	Interaction	Organism	Category

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

The following transcription factors affect gene expression:

• AP-2gamma
• p300

Tissue specificity:

Isoform 2 is expressed in normal intestinal tissue as well as in colorectal carcinomas.

Induction:

Up-regulated following treatment with IFNG/IFN-gamma.

Enzyme Regulation:

Activated by Ca(2+)/calmodulin. Regulated by a locking mechanism, involving autophosphorylation at Ser-308 and calmodulin binding. In the inactive state, Ser-308 is phosphorylated. Activation involves its dephosphorylation and a release-of-autoinhibition mechanism where binding of calmodulin induces a conformational change that relieves the steric block of the active site by the autoinhibitory domain. Activity is modulated by UNC5B and NTN1. UNC5B activates it by inhibiting the phosphorylation at Ser-308, whereas NTN1 inhibits UNC5B-mediated activation of DAPK1. Endoplasmic-stress activates by causing Ser-308 dephosphorylation.

Molecular Function:

• Atp Binding
• Calmodulin Binding
• Calmodulin-Dependent Protein Kinase Activity
• Gtp Binding
• Identical Protein Binding
• Protein Serine/Threonine Kinase Activity
• Syntaxin-1 Binding

Biological Processes:

• Apoptotic Process
• Apoptotic Signaling Pathway
• Cellular Response To Interferon-Gamma
• Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
• Intracellular Signal Transduction
• Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
• Negative Regulation Of Translation
• Positive Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
• Protein Autophosphorylation
• Protein Phosphorylation
• Regulation Of Apoptotic Process
• Regulation Of Autophagy
• Regulation Of N-Methyl-D-Aspartate Selective Glutamate Receptor Activity

*synonyms