• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. DAO

DAO (D-amino acid oxidase)

Loading...

Summary of DAO

DAO encodes for D-amino acid oxidase, but the enzyme's biological functions are unknown (R;).

High/excess amounts of DAO are found in schizophrenic patients, so it might play a role in schizophrenia (R;).

0 users want this gene increased, 0 users want it decreased

The Function of DAO

Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.

Protein names

Recommended name:

D-amino-acid oxidase

Short name:

DAO

Alternative name(s):

DAAO
DAMOX

DAO SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2070586 (DAO) ??
  2. RS2111902 (DAO) ??
  3. RS3741775 (DAO) ??
  4. RS3825251 (DAO) ??
  5. RS4623951 (DAO) ??

Top Gene-Substance Interactions

Substances That Increase DAO

Substances Interaction Organism Category

Substances That Decrease DAO

Substances Interaction Organism Category

Advanced Summary

DAO encodes for D-amino acid oxidase, but the enzyme's biological functions are unknown (R;).

High/excess amounts of DAO are found in schizophrenic patients, so it might play a role in schizophrenia (R;).

     From NCBI Gene: Schizophrenia

     From NCBI Gene: This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008] From UniProt: Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Peroxisome
  • Arginine and proline metabolism
  • Glycine, serine and threonine metabolism
  • D-Arginine and D-ornithine metabolism

Molecular Function:

  • Cofactor Binding
  • D-Amino-Acid Oxidase Activity
  • Fad Binding
  • Protein Dimerization Activity
  • Receptor Binding

Biological Processes:

  • D-Alanine Catabolic Process
  • D-Amino Acid Metabolic Process
  • Dopamine Biosynthetic Process
  • D-Serine Catabolic Process
  • D-Serine Metabolic Process
  • Glyoxylate Metabolic Process
  • Proline Catabolic Process

Drug Bank:

  • Flavin Adenine Dinucleotide
  • Benzoic Acid
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| null| dao| anon-WO0140519.126| AS27_00779| AS28_06334| BG:DS07295.2| CB1_000253012| CG15267 gene product from transcript CG15267-RB| CG15267-PA| CG15267-PB| CG15267-PC| daao| D-amino-acid oxidase| D-amino acid oxidase 1| D-amino acid oxidase-like protein| DAMOX| Dao1| Dao-1| dao-PA| dao-PB| dao-PC| Dmel_CG15267| down and out| EGK_04155| GW7_02141| H920_14948| I79_010357| M91_17586| M959_06901| N300_10317| N301_08479| N302_01385| N305_13776| N307_00945| N310_00330| N312_04336| N321_09453| N322_06401| N326_07938| N327_13140| N328_05347| N330_08117| N332_01924| N333_03482| N334_02078| N336_09739| N339_03504| N340_07756| OXDA| PAL_GLEAN10002729| PANDA_010169| TREES_T100018645| Y1Q_017121| Z169_08047

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved