Summary of DAO
The Function of DAO
Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
Protein names
Recommended name:
D-amino-acid oxidaseShort name:
DAOAlternative name(s):
DAAODAMOX
- RS2070586 (DAO) ??
- RS2111902 (DAO) ??
- RS3741775 (DAO) ??
- RS3825251 (DAO) ??
- RS4623951 (DAO) ??
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Top Gene-Substance Interactions
Substances That Increase DAO
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Substances That Decrease DAO
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Advanced Summary
DAO encodes for D-amino acid oxidase, but the enzyme's biological functions are unknown (R;).
High/excess amounts of DAO are found in schizophrenic patients, so it might play a role in schizophrenia (R;).
From NCBI Gene: Schizophrenia
From NCBI Gene: This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008] From UniProt: Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- D-Amino-Acid Oxidase Activity
- Receptor Binding
- Protein Dimerization Activity
- Cofactor Binding
- Fad Binding
Biological Processes:
- Proline Catabolic Process
- D-Serine Catabolic Process
- Dopamine Biosynthetic Process
- D-Amino Acid Metabolic Process
- Glyoxylate Metabolic Process
- D-Alanine Catabolic Process
- D-Serine Metabolic Process
Drug Bank:
- Flavin Adenine Dinucleotide
- Benzoic Acid