The Function of DAG1
(Microbial infection) Alpha-dystroglycan acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class C new-world arenaviruses (PubMed:16254364, PubMed:19324387, PubMed:17360738). Alpha-dystroglycan acts as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy, but only in the presence of the G-domain of LAMA2 (PubMed:9851927).
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Protein names
Recommended name:
DystroglycanAlternative name(s):
Dystrophin-associated glycoprotein 1Alpha-DG
Beta-DG
- RS142316462 (DAG1) ??
- RS4625 (DAG1) ??
- RS7647973 (DAG1) ??
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Top Gene-Substance Interactions
DAG1 Interacts with These Diseases
| Disease | Score |
Substances That Increase DAG1
| Substances | Interaction | Organism | Category |
Substances That Decrease DAG1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in a variety of fetal and adult tissues. In epidermal tissue, located to the basement membrane. Also expressed in keratinocytes and fibroblasts.
Gene Pathways:
Molecular Function:
- Virus Receptor Activity
- Actin Binding
- Calcium Ion Binding
- Structural Constituent Of Muscle
- Tubulin Binding
- Vinculin Binding
- Sh2 Domain Binding
- Laminin-1 Binding
- Alpha-Actinin Binding
Biological Processes:
- Morphogenesis Of An Epithelial Sheet
- Protein O-Linked Glycosylation
- Membrane Protein Ectodomain Proteolysis
- Nls-Bearing Protein Import Into Nucleus
- Cytoskeletal Anchoring At Plasma Membrane
- Regulation Of Gastrulation
- Regulation Of Epithelial To Mesenchymal Transition
- Calcium-Dependent Cell-Matrix Adhesion
- Regulation Of Embryonic Cell Shape
- Modulation By Virus Of Host Morphology Or Physiology
- Nerve Maturation
- Myelination In Peripheral Nervous System
- Extracellular Matrix Organization
- Negative Regulation Of Cell Migration
- Microtubule Anchoring
- Negative Regulation Of Mapk Cascade
- Response To Peptide Hormone
- Negative Regulation Of Protein Kinase B Signaling
- Epithelial Tube Branching Involved In Lung Morphogenesis
- Branching Involved In Salivary Gland Morphogenesis
- Commissural Neuron Axon Guidance
- Basement Membrane Organization
- Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis