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  3. DAG1

DAG1 (Dystroglycan 1)

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The Function of DAG1

(Microbial infection) Alpha-dystroglycan acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class C new-world arenaviruses (PubMed:16254364, PubMed:19324387, PubMed:17360738). Alpha-dystroglycan acts as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy, but only in the presence of the G-domain of LAMA2 (PubMed:9851927).

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Protein names

Recommended name:

Dystroglycan

Alternative name(s):

Dystrophin-associated glycoprotein 1
Alpha-DG
Beta-DG

DAG1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS142316462 (DAG1) ??
  2. RS4625 (DAG1) ??
  3. RS7647973 (DAG1) ??

Top Gene-Substance Interactions

DAG1 Interacts with These Diseases

Disease Score

Substances That Increase DAG1

Substances Interaction Organism Category

Substances That Decrease DAG1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • Max
  • c-Jun
  • NF-kappaB1
  • c-Myc

Tissue specificity:

Expressed in a variety of fetal and adult tissues. In epidermal tissue, located to the basement membrane. Also expressed in keratinocytes and fibroblasts.

Gene Pathways:

  • Arrhythmogenic right ventricular cardiomyopathy (ARVC)
  • Extracellular matrix organization
  • Dilated cardiomyopathy
  • Hypertrophic cardiomyopathy (HCM)
  • Viral myocarditis

Molecular Function:

  • Actin Binding
  • Alpha-Actinin Binding
  • Calcium Ion Binding
  • Laminin-1 Binding
  • Sh2 Domain Binding
  • Structural Constituent Of Muscle
  • Tubulin Binding
  • Vinculin Binding
  • Virus Receptor Activity

Biological Processes:

  • Basement Membrane Organization
  • Branching Involved In Salivary Gland Morphogenesis
  • Calcium-Dependent Cell-Matrix Adhesion
  • Commissural Neuron Axon Guidance
  • Cytoskeletal Anchoring At Plasma Membrane
  • Epithelial Tube Branching Involved In Lung Morphogenesis
  • Extracellular Matrix Organization
  • Membrane Protein Ectodomain Proteolysis
  • Microtubule Anchoring
  • Modulation By Virus Of Host Morphology Or Physiology
  • Morphogenesis Of An Epithelial Sheet
  • Myelination In Peripheral Nervous System
  • Negative Regulation Of Cell Migration
  • Negative Regulation Of Mapk Cascade
  • Negative Regulation Of Protein Kinase B Signaling
  • Nerve Maturation
  • Nls-Bearing Protein Import Into Nucleus
  • Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis
  • Protein O-Linked Glycosylation
  • Regulation Of Embryonic Cell Shape
  • Regulation Of Epithelial To Mesenchymal Transition
  • Regulation Of Gastrulation
  • Response To Peptide Hormone
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| glycine cleavage system T-protein| 156dag| A3a| AGRNR| alpha-dystroglycan| AS27_03170| AS28_00663| beta-dystroglycan| CB1_000145053| D623_10011431| D9Wsu13e| dag| dg| Dp427| Dp71| Dystroglycan| dystroglycan 1 (dystrophin-associated glycoprotein 1)| dystroglycan preproprotein| dystrophin-associated glycoprote| dystrophin associated glycoprotein 1| dystrophin-associated glycoprotein 1| H920_20018| I79_006654| M959_05670| MDA_GLEAN10023173| MDDGA9| MDDGC7| MDDGC9| N300_09950| N301_01279| N302_10064| N303_15589| N306_05626| N308_08444| N310_03902| N312_03285| N320_01017| N321_06241| N322_07010| N327_03030| N330_08142| N331_04009| N333_13657| N334_01344| N335_04944| N336_10843| N339_02196| PAL_GLEAN10009186| PANDA_009346| RAB7| RAB7, member RAS oncogene family| Y1Q_007652| Z169_15885| dag1

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