Summary of DAB2IP
This gene encodes a GTPase-activating protein that acts as a tumor suppressor (R).
The Function of DAB2IP
Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to proinflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Mediates also TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6) and Ras. Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Functions also as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively.
Protein names
Recommended name:
Disabled homolog 2-interacting proteinShort name:
AIP-1Alternative name(s):
DAB2 interaction proteinDAB2-interacting protein
ASK-interacting protein 1
DOC-2/DAB-2 interactive protein
- RS10760187 (DAB2IP) ??
- RS10818593 (DAB2IP) ??
- RS10985375 (DAB2IP) ??
- RS13264970 (DAB2IP) ??
- RS1571801 (DAB2IP) ??
- RS2219968 (DAB2IP) ??
- RS35061590 (DAB2IP) ??
- RS3747851 (DAB2IP) ??
- RS7025486 (DAB2IP) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
DAB2IP Interacts with These Diseases
Disease | Score |
Substances That Increase DAB2IP
Substances | Interaction | Organism | Category |
Substances That Decrease DAB2IP
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
---|
Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in endothelial and vascular smooth muscle cells (VSMCs). Expressed in prostate epithelial but poorly in prostate cancer cells. Poorly expressed in medulloblastoma cells compared to cerebellar precursor proliferating progenitor cells (at protein level). Low expression in prostate. Down-regulated in prostate cancer.
Induction:
Down-regulated in prostate cancer and medulloblastoma.
Molecular Function:
- 14-3-3 Protein Binding
- Cadherin Binding Involved In Cell-Cell Adhesion
- Death Receptor Binding
- Gtpase Activator Activity
- Kinase Binding
- Mitogen-Activated Protein Kinase Kinase Binding
- Mitogen-Activated Protein Kinase Kinase Kinase Binding
- Phosphatidylinositol 3-Kinase Binding
- Phosphatidylinositol 3-Kinase Regulatory Subunit Binding
- Phosphatidylinositol-3-Phosphate Binding
- Phosphatidylinositol-4-Phosphate Binding
- Protein Complex Binding
- Protein Homodimerization Activity
- Protein Kinase Binding
- Protein Phosphatase 2a Binding
- Sh3 Domain Binding
- Signaling Adaptor Activity
- Vascular Endothelial Growth Factor Receptor 2 Binding
- Identical Protein Binding
Biological Processes:
- Activation Of Jun Kinase Activity
- Activation Of Mapkkk Activity
- Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
- Angiogenesis
- Cell Cycle
- Cell Motility Involved In Cerebral Cortex Radial Glia Guided Migration
- Cellular Protein Catabolic Process
- Cellular Response To Epidermal Growth Factor Stimulus
- Cellular Response To Interleukin-1
- Cellular Response To Lipopolysaccharide
- Cellular Response To Tumor Necrosis Factor
- Cellular Response To Vascular Endothelial Growth Factor Stimulus
- Endothelial Cell Apoptotic Process
- Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
- I-Kappab Phosphorylation
- Inflammatory Response
- Innate Immune Response
- Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
- Layer Formation In Cerebral Cortex
- Mapk Cascade
- Negative Regulation Of Angiogenesis
- Negative Regulation Of Canonical Wnt Signaling Pathway
- Negative Regulation Of Catenin Import Into Nucleus
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Cellular Protein Catabolic Process
- Negative Regulation Of Endothelial Cell Migration
- Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
- Negative Regulation Of Epithelial Cell Migration
- Negative Regulation Of Epithelial Cell Proliferation
- Negative Regulation Of Epithelial To Mesenchymal Transition
- Negative Regulation Of Erk1 And Erk2 Cascade
- Negative Regulation Of Fibroblast Proliferation
- Negative Regulation Of G0 To G1 Transition
- Negative Regulation Of Gtpase Activity
- Negative Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Negative Regulation Of Map Kinase Activity
- Negative Regulation Of Nf-Kappab Transcription Factor Activity
- Negative Regulation Of Phosphatidylinositol 3-Kinase Activity
- Negative Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Negative Regulation Of Protein Phosphorylation
- Negative Regulation Of Protein Serine/Threonine Kinase Activity
- Negative Regulation Of Ras Protein Signal Transduction
- Negative Regulation Of Toll-Like Receptor 4 Signaling Pathway
- Negative Regulation Of Transcription, Dna-Templated
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
- Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
- Neuron Projection Morphogenesis
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of Apoptotic Signaling Pathway
- Positive Regulation Of Cell Cycle Arrest
- Positive Regulation Of Dendrite Development
- Positive Regulation Of Ire1-Mediated Unfolded Protein Response
- Positive Regulation Of Jnk Cascade
- Positive Regulation Of Jun Kinase Activity
- Positive Regulation Of Mapk Cascade
- Positive Regulation Of Neuron Migration
- Positive Regulation Of Neuron Projection Development
- Positive Regulation Of Proteasomal Protein Catabolic Process
- Positive Regulation Of Protein Catabolic Process
- Positive Regulation Of Protein Serine/Threonine Kinase Activity
- Positive Regulation Of Synapse Maturation
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Reelin-Mediated Signaling Pathway
- Regulation Of Growth
- Regulation Of Gtpase Activity
- Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Regulation Of P38mapk Cascade
- Regulation Of Protein Heterodimerization Activity
- Tube Formation
- Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway