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  3. CYP8B1

CYP8B1 (Cytochrome P450 family 8 subfamily B member 1)

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The Function of CYP8B1

Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids.

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Protein names

Recommended name:

7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase

Short name:

CYPVIIIB1

Alternative name(s):

7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase
Cytochrome P450 8B1
Sterol 12-alpha-hydroxylase

CYP8B1 SNPs

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  1. RS3919627 (CYP8B1) ??

Top Gene-Substance Interactions

CYP8B1 Interacts with These Diseases

Disease Score

Substances That Increase CYP8B1

Substances Interaction Organism Category

Substances That Decrease CYP8B1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun
  • HNF-4alpha1
  • HNF-4alpha2

Tissue specificity:

Liver.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Disease
  • PPAR signaling pathway
  • Primary bile acid biosynthesis

Molecular Function:

  • 7alpha-Hydroxycholest-4-En-3-One 12alpha-Hydroxylase Activity
  • Heme Binding
  • Iron Ion Binding
  • Oxygen Binding
  • Sterol 12-Alpha-Hydroxylase Activity

Biological Processes:

  • Bile Acid Biosynthetic Process
  • Sterol Metabolic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase| 7 alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase| 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase| 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase| CP8B| CYP12| CYP8B| CYPVIIIB1| cytochrome P-450 8B1| cytochrome P450 8B1| cytochrome P450, 8b1, sterol 12 alpha-hydrolase| cytochrome P450, family 8, subfamily B| cytochrome P450, family 8, subfamily B, polypeptide 1| cytochrome P450, subfamily VIIIB (sterol 12-alpha-hydroxylase), polypeptide 1| sterol 12-alpha-hydrolase| sterol 12-alpha hydroxylase| sterol 12-alpha-hydroxylase| sterol 12alpha-hydroxylase| cyp8b1

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