The Function of CYP8B1
Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids.
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Protein names
Recommended name:
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylaseShort name:
CYPVIIIB1Alternative name(s):
7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylaseCytochrome P450 8B1
Sterol 12-alpha-hydroxylase
- RS3919627 (CYP8B1) ??
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Top Gene-Substance Interactions
CYP8B1 Interacts with These Diseases
| Disease | Score |
Substances That Increase CYP8B1
| Substances | Interaction | Organism | Category |
Substances That Decrease CYP8B1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Liver.
Gene Pathways:
Molecular Function:
- 7alpha-Hydroxycholest-4-En-3-One 12alpha-Hydroxylase Activity
- Heme Binding
- Iron Ion Binding
- Oxygen Binding
- Sterol 12-Alpha-Hydroxylase Activity