Summary of CYP7A1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The enzymes catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids (R).
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0 users want it decreased
The Function of CYP7A1
Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis.
Protein names
Recommended name:
Cholesterol 7-alpha-monooxygenaseShort name:
CYPVIIAlternative name(s):
Cholesterol 7-alpha-hydroxylaseCytochrome P450 7A1
- RS1457043 (CYP7A1) ??
- RS2081687 (CYP7A1) ??
- RS3808607 (CYP7A1) ??
- RS3824260 (CYP7A1) ??
- RS4738684 (CYP7A1) ??
- RS8192879 (CYP7A1) ??
- RS9297994 (CYP7A1) ??
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Top Gene-Substance Interactions
CYP7A1 Interacts with These Diseases
| Disease | Score |
Fixes
Methods to Reduce CYP7A1 levels:
- Increased levels of FXR protein [R].
Substances That Increase CYP7A1
| Substances | Interaction | Organism | Category |
Substances That Decrease CYP7A1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in liver.
Gene Pathways:
Induction:
Up-regulated by glucose and by cholestyramine. Down-regulated by chenodeoxycholic acid.
Molecular Function:
Biological Processes:
- Bile Acid Biosynthetic Process
- Cellular Response To Cholesterol
- Cellular Response To Glucose Stimulus
- Cholesterol Catabolic Process
- Cholesterol Homeostasis
- Regulation Of Bile Acid Biosynthetic Process
- Sterol Metabolic Process